The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses.
The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses.
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DOI：
10.3390/jof9080787
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发表时间：
2023-07-26
期刊：
影响因子：
4.7
通讯作者：
Nicastro, Raffaele
中科院分区：
文献类型：
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作者：
Caligaris, Marco;Sampaio-Marques, Belem;Hatakeyama, Riko;Pillet, Benjamin;Ludovico, Paula;De Virgilio, Claudio;Winderickx, Joris;Nicastro, Raffaele
酵母细胞配备有不同的营养信号通路，使它们能够感知各种营养物质的可用性，并相应地调整代谢和生长。这些途径是一个复杂网络的一部分，因为它们中的大多数是交叉调节的，并受到不同水平的反馈调节。在酵母中，一个中心的作用是由Sch9，蛋白激酶，作为保守的生长调节TORC 1复合物的近端效应介导的信息的可用性的游离氨基酸。然而，最近的研究表明，Sch9不仅仅是一个TORC1效应子，因为它的活性是由其他几种激酶调节的。这使得Sch9可以作为一个整合器，调整不同的输入信号，以实现代谢反应和应激相关分子适应的准确性。在这篇综述中，我们重点介绍了Sch9结构和调控的最新发现，以及它作为营养反应中心的作用，影响酵母细胞的生长和寿命。鉴于大多数影响Sch9的关键参与者都很保守，我们还讨论了Sch9的研究如何有助于进一步阐明支持健康老龄化的机制。
Yeast cells are equipped with different nutrient signaling pathways that enable them to sense the availability of various nutrients and adjust metabolism and growth accordingly. These pathways are part of an intricate network since most of them are cross-regulated and subject to feedback regulation at different levels. In yeast, a central role is played by Sch9, a protein kinase that functions as a proximal effector of the conserved growth-regulatory TORC1 complex to mediate information on the availability of free amino acids. However, recent studies established that Sch9 is more than a TORC1-effector as its activity is tuned by several other kinases. This allows Sch9 to function as an integrator that aligns different input signals to achieve accuracy in metabolic responses and stress-related molecular adaptations. In this review, we highlight the latest findings on the structure and regulation of Sch9, as well as its role as a nutrient-responsive hub that impacts on growth and longevity of yeast cells. Given that most key players impinging on Sch9 are well-conserved, we also discuss how studies on Sch9 can be instrumental to further elucidate mechanisms underpinning healthy aging in mammalians.
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影响因子：
9.9
作者：
Cowart, L. Ashley;Shotwell, Matthew;Worley, Mitchell L.;Richards, Adam J.;Montefusco, David J.;Hannun, Yusuf A.;Lu, Xinghua
通讯作者：
Lu, Xinghua
DOI：
10.1083/jcb.200707154
发表时间：
2008-01-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Madia F;Gattazzo C;Wei M;Fabrizio P;Burhans WC;Weinberger M;Galbani A;Smith JR;Nguyen C;Huey S;Comai L;Longo VD
通讯作者：
Longo VD
映射SNF1与酿酒酵母中TORC1的相互作用。
影响因子：
9.9
作者：
通讯作者：
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影响因子：
3.7
作者：
Cocklin R;Goebl M
通讯作者：
Goebl M
影响因子：
4.5
作者：
通讯作者：
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