Comparing hippocampal atrophy in Alzheimer's dementia and dementia with lewy bodies.
Comparing hippocampal atrophy in Alzheimer's dementia and dementia with lewy bodies.
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DOI：
10.1159/000339727
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发表时间：
2012
影响因子：
2.4
通讯作者：
Apostolova LG
中科院分区：
文献类型：
--
作者：
Chow N;Aarsland D;Honarpisheh H;Beyer MK;Somme JH;Elashoff D;Rongve A;Tysnes OB;Thompson PM;Apostolova LG
路易体痴呆（DLB）和阿尔茨海默病（AD）是两种最常见的神经退行性痴呆。在早期阶段，它们之间的临床区分往往具有挑战性。我们的目的是比较轻度AD和轻度DLB的海马萎缩模式。我们假设DLB受试者相对于AD受试者具有较轻的海马萎缩。我们分析了113例受试者的T1加权磁共振成像数据：55例AD，16例DLB和42例认知正常老年人（NC）。使用海马径向距离技术和多元线性回归，我们分析了临床诊断对海马径向距离的影响，同时调整了性别和年龄。使用基于置换的统计学调整3D统计图用于多重比较，阈值为p<0.01。与NC相比，AD表现出显著更大的萎缩，在角Ammonis（CA）1，CA 2 -3和下托区域的双边，而DLB表现出左侧为主的萎缩，在CA 1区和下托。AD和DLB直接比较没有显示统计学显著性差异。与NC相比，轻度受损DLB受试者中存在的海马萎缩的严重程度低于轻度受损AD受试者中观察到的萎缩。两组均显示CA 1亚区和下托明显萎缩。
Dementia with Lewy Bodies (DLB) and Alzheimer's disease (AD) are the two most common neurodegenerative dementias. During the early stages, clinical distinction between them is often challenging. Our objective is to compare hippocampal atrophy patterns in mild AD and mild DLB. We hypothesized that DLB subjects have milder hippocampal atrophy relative to AD subjects. We analyzed the T1-weighted magnetic resonance imaging data from 113 subjects: 55 AD, 16 DLB and 42 cognitively normal elderly (NC). Using the hippocampal radial distance technique and multiple linear regression, we analyzed the effect of clinical diagnosis on hippocampal radial distance, while adjusting for gender and age. 3D statistical maps were adjusted for multiple comparisons using permutation-based statistics with a threshold of p<0.01. Compared to NC, AD exhibited significantly greater atrophy in the Cornu Ammonis (CA) 1, CA2-3 and subicular regions bilaterally while DLB showed left-predominant atrophy in the CA1 region and subiculum. AD and DLB directly compared did not reveal statistically significant differences. Hippocampal atrophy, while present in mildly impaired DLB subjects, is less severe than atrophy seen in mildly impaired AD subjects, when compared to NC. Both groups show predominant atrophy of the CA1 subfield and subiculum.
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影响因子：
12.7
作者：
Hortobagyi, Tibor;Troakes, Claire;Shaw, Christopher E.
通讯作者：
Shaw, Christopher E.
影响因子：
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作者：
Mueller, S. G.;Schuff, N.;Weiner, M. W.
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Kirvell, S. L.;Elliott, M. S.;Francis, P. T.
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Francis, P. T.
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9.9
作者：
Aarsland, D.;Bronnick, K.;Alves, G.
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Alves, G.
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4.8
作者：
Apostolova, Liana G.;Thompson, Paul M.;Green, Amity E.;Hwang, Kristy S.;Zoumalan, Charleen;Jack, Clifford R., Jr.;Harvey, Danielle J.;Petersen, Ronald C.;Thal, Leon J.;Aisen, Paul S.;Toga, Arthur W.;Cummings, Jeffrey L.;DeCarli, Charles S.
通讯作者：
DeCarli, Charles S.