A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans.
A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans.
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DOI：
10.1038/nature07886
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发表时间：
2009-04-30
期刊：
影响因子：
64.8
通讯作者：
Bargmann, Cornelia I.
中科院分区：
文献类型：
--
作者：
Macosko, Evan Z.;Pokala, Navin;Feinberg, Evan H.;Chalasani, Sreekanth H.;Butcher, Rebecca A.;Clardy, Jon;Bargmann, Cornelia I.
天生的社会行为来自神经回路，这些神经回路根据个体自身的基因型、性别和经验来解释感官信息。对C.线虫，一种只有302个神经元的简单动物，是分析这些回路的一个有吸引力的系统。秀丽隐杆线虫的野生社会菌株在特定的感官线索的存在下聚集，但孤独的菌株不。在这里，我们确定RMG间/运动神经元作为控制聚集和相关行为的调节回路的枢纽。RMG是神经肽受体基因npr-1的中心作用位点，它将孤独菌株（高npr-1活性）与野生社会菌株（低npr-1活性）区分开来;高RMG活性对社会行为的各个方面都是必不可少的。解剖学缝隙连接RMG连接到已知促进聚集的多种感觉神经元，并连接到ASK感觉神经元，其涉及雄性对雌雄同体信息素的吸引。我们发现，ASK神经元直接响应信息素，高RMG活性增强ASK反应的社会菌株，导致雌雄同体吸引信息素的浓度，排斥孤独的雌雄同体。RMG对社会行为的协调提示了集合中感觉整合的解剖学轴辐模型，并指出了C。elegans接线图
Innate social behaviors emerge from neuronal circuits that interpret sensory information based on an individual's own genotype, sex, and experience. The regulated aggregation behavior of C. elegans, a simple animal with only 302 neurons, is an attractive system to analyze these circuits. Wild social strains of the nematode Caenorhabditis elegans aggregate in the presence of specific sensory cues, but solitary strains do not. Here we identify the RMG inter/motor neuron as the hub of a regulated circuit that controls aggregation and related behaviors. RMG is the central site of action of the neuropeptide receptor gene npr-1, which distinguishes solitary strains (high npr-1 activity) from wild social strains (low npr-1 activity); high RMG activity is essential for all aspects of social behavior. Anatomical gap junctions connect RMG to multiple classes of sensory neurons known to promote aggregation, and to ASK sensory neurons, which are implicated in male attraction to hermaphrodite pheromones. We find that ASK neurons respond directly to pheromones, and that high RMG activity enhances ASK responses in social strains, causing hermaphrodite attraction to pheromones at concentrations that repel solitary hermaphrodites. The coordination of social behaviors by RMG suggests an anatomical hub-and-spoke model for sensory integration in aggregation, and points to functions for related circuit motifs in the C. elegans wiring diagram.
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