Cyclic estradiol treatment modulates the orexigenic effects of ghrelin in ovariectomized rats.
Cyclic estradiol treatment modulates the orexigenic effects of ghrelin in ovariectomized rats.
复制标题
DOI：
10.1016/j.pbb.2014.07.004
复制
发表时间：
2014-09
影响因子：
3.6
通讯作者：
Bungo, Alexandria
中科院分区：
文献类型：
--
作者：
Butera, Peter C.;Clough, Shannon J.;Bungo, Alexandria
来自多种哺乳动物物种的数据表明，摄食行为可以受到内源性雌激素和外源性雌激素治疗的变化的影响。Ghrelin是调节能量平衡的重要生理信号，Ghrelin处理增加雄性啮齿动物的进食和体重。以下研究通过检查雌二醇调节雌性大鼠中生长激素释放肽的行为效应的能力，评估了雌二醇对摄食的抑制作用涉及与食欲肽的相互作用的假设。在这些实验中，成年大鼠卵巢切除，并分配到苯甲酸雌二醇（EB）或油（对照）组。卵巢切除术后三周，动物每天接受两次皮下注射EB或油载体。然后在第一次注射雌二醇或油后三天，在夜间和白天期间，动物接受腹膜内（ip）注射生长激素释放肽（6.0或12.0 nmol）或盐水。在胃饥饿素或盐水处理后的2小时期间确定食物摄入、膳食大小和膳食数量。Ghrelin显着增加食物摄入量在夜间试验中油处理，但没有雌二醇处理的大鼠。胃饥饿素对夜间食物摄入量的hyperphagic作用也伴随着膳食量的增加，而这种胃饥饿素对膳食量的影响在雌二醇治疗的女性中减弱。这些发现支持了这样的假设：雌激素对进食行为的影响涉及食欲信号的减弱，可能是通过调节外周胃饥饿素信号对参与控制食物摄入的下丘脑神经肽的影响。
Data from a wide variety of mammalian species indicate that feeding behavior can be influenced by changes in endogenous estrogens and exogenous estrogenic treatments. Ghrelin is an important physiological signal for the regulation of energy balance, and ghrelin treatment increases eating and body weight in male rodents. The following studies evaluated the hypothesis that the inhibitory effects of estradiol on feeding involve interactions with orexigenic peptides by examining the ability of estradiol to modulate the behavioral effects of ghrelin in female rats. In these experiments, adult rats were ovariectomized and assigned to an estradiol benzoate (EB) or oil (control) group. Three weeks after ovariectomy, animals received two daily subcutaneous injections of EB or the oil vehicle. Animals then received intraperitoneal (ip) injections of ghrelin (6.0 or 12.0 nmol) or saline during the nocturnal and diurnal periods three days after the first injection of estradiol or oil. Food intake, meal size, and meal number were determined during the 2-hour period following ghrelin or saline treatments. Ghrelin significantly increased food intake during nocturnal tests in oil-treated but not estradiol-treated rats. The hyperphagic effects of ghrelin on nocturnal food intake were also accompanied by an increase in meal size, and this effect of ghrelin on meal size was attenuated in estradiol-treated females. These findings support the hypothesis that the effects of estradiol on feeding behavior involve an attenuation of orexigenic signals, possibly by modulating the effects of the peripheral ghrelin signal on hypothalamic neuropeptides involved in the control of food intake.
登录
查看更多内容
影响因子：
2.9
作者：
Butera, Peter C.;Wojcik, Danielle M.;Clough, Shannon J.
通讯作者：
Clough, Shannon J.
影响因子：
3
作者：
Eckel, LA;Geary, N
通讯作者：
Geary, N
影响因子：
3
作者：
Davidson, TL;Kanoski, SE;Benoit, SC
通讯作者：
Benoit, SC
影响因子：
2.9
作者：
Butera, Peter C.
通讯作者：
Butera, Peter C.
DOI：
10.1006/bbrc.2002.6737
发表时间：
2002-04-12
影响因子：
3.1
作者：
Beck, B;Musse, N;Stricker-Krongrad, A
通讯作者：
Stricker-Krongrad, A