Memory and eating: A bidirectional relationship implicated in obesity.
Memory and eating: A bidirectional relationship implicated in obesity.
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DOI：
10.1016/j.neubiorev.2021.10.051
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发表时间：
2022-01
影响因子：
8.2
通讯作者：
Kanoski SE
中科院分区：
文献类型：
--
作者：
Parent MB;Higgs S;Cheke LG;Kanoski SE
本文综述了表明人类和啮齿动物中记忆与饮食之间存在双向关系的证据。在人类中，失忆与饥饿和饱腹感线索处理受损、近期进食记忆紊乱以及过度进食有关。在健康参与者中，与进食相关的记忆会限制后续的摄食行为，并且肥胖与记忆受损以及海马体紊乱有关。来自啮齿动物的证据表明，背侧海马体的神经活动有助于与进食相关的记忆控制未来摄入量的能力，内分泌和神经肽系统在腹侧海马体中起作用，提供有关能量状态的线索并调节进食的习得方面，而且高热量饮食的摄入和肥胖会扰乱这些过程。总体而言，这些证据表明，饮食诱导的肥胖可能至少部分是由一个恶性循环引起和/或维持的，在这个循环中，过量摄入会扰乱海马体功能，进而进一步增加摄入量。这一观点可能会增进我们对大脑如何控制进食、导致进食相关障碍的神经机制的理解，并确定如何治疗饮食诱导的肥胖。
This paper reviews evidence demonstrating a bidirectional relationship between memory and eating in humans and rodents. In humans, amnesia is associated with impaired processing of hunger and satiety cues, disrupted memory of recent meals, and overconsumption. In healthy participants, meal-related memory limits subsequent ingestive behavior and obesity is associated with impaired memory and disturbances in the hippocampus. Evidence from rodents suggests that dorsal hippocampal neural activity contributes to the ability of meal-related memory to control future intake, that endocrine and neuropeptide systems act in the ventral hippocampus to provide cues regarding energy status and regulate learned aspects of eating, and that consumption of hypercaloric diets and obesity disrupt these processes. Collectively, this evidence indicates that diet-induced obesity may be caused and/or maintained, at least in part, by a vicious cycle wherein excess intake disrupts hippocampal functioning, which further increases intake. This perspective may advance our understanding of how the brain controls eating, the neural mechanisms that contribute to eating-related disorders, and identify how to treat diet-induced obesity.
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