The ghosts of HeLa: How cell line misidentification contaminates the scientific literature.

The ghosts of HeLa: How cell line misidentification contaminates the scientific literature.
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DOI:
10.1371/journal.pone.0186281
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发表时间:
2017
期刊:
影响因子:
3.7
通讯作者:
Halffman W
Halffman W
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Horbach SPJM;Halffman W

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虽然细胞系错误识别的问题已经存在了几十年,但仍有数量不详的已发表论文在流通中报告错误的细胞,而没有警告或纠正。在这里,我们试图作出保守的估计,这种“污染”的文献。我们发现有32,755篇文章报道了错误识别细胞的研究,这些文章被估计有50万篇其他论文引用。文献的污染并没有随着时间的推移而减少,而且绝不限于全球科学边缘的国家。几十年来,人们一直试图阻止细胞系的错误识别,但这一努力往往是有争议的,已经证明是不够的。文献的污染需要一个公平合理的通知系统,警告用户和读者以适当的谨慎来解释这些论文。
While problems with cell line misidentification have been known for decades, an unknown number of published papers remains in circulation reporting on the wrong cells without warning or correction. Here we attempt to make a conservative estimate of this ‘contaminated’ literature. We found 32,755 articles reporting on research with misidentified cells, in turn cited by an estimated half a million other papers. The contamination of the literature is not decreasing over time and is anything but restricted to countries in the periphery of global science. The decades-old and often contentious attempts to stop misidentification of cell lines have proven to be insufficient. The contamination of the literature calls for a fair and reasonable notification system, warning users and readers to interpret these papers with appropriate care.
278 种广泛使用的肿瘤细胞系交叉污染和误识别的调查
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