Episodic memory and appetite regulation in humans.
Episodic memory and appetite regulation in humans.
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DOI：
10.1371/journal.pone.0050707
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ferriday D
中科院分区：
文献类型：
--
作者：
Brunstrom JM;Burn JF;Sell NR;Collingwood JM;Rogers PJ;Wilkinson LL;Hinton EC;Maynard OM;Ferriday D
心理学和神经生物学证据表明，饥饿和食物摄入的控制涉及依赖于大脑的记忆过程。在人类中，这些已经在与健忘症相关的暴食症中被揭示出来。然而，目前还不清楚“最近进食的记忆”是否在神经系统完整的人类中起着重要作用。在这项研究中，我们分离了最近吃过的一顿饭的记忆在三小时内对饥饿和饱腹感的影响程度。午餐前，一半的志愿者被要求喝300毫升的汤，另一半则被要求喝500毫升。与此正交，一半消耗300 ml，一半消耗500 ml。这一过程产生了四个独立的小组（每组25名志愿者）。使用计算机控制的蠕动泵实现了对“实际”和“感知”汤部分的独立操纵。这被设计成以隐蔽的方式从汤碗中重新填充或吸取汤。午餐后，自我报告的饥饿感受到实际摄入的汤量的影响，而不是感知的汤量。然而，在用餐结束后两三小时，这种模式被逆转-饥饿是由感知量而不是实际量预测的。那些认为他们已经消耗了较大的500毫升部分的参与者报告饥饿感明显减少。这也与24小时后汤的“预期饱腹感”增加有关。这是第一次，这种操纵暴露了独立的和重要的贡献，记忆过程的饱足感。利用这一发现来减少人类能量摄入的机会是存在的。
Psychological and neurobiological evidence implicates hippocampal-dependent memory processes in the control of hunger and food intake. In humans, these have been revealed in the hyperphagia that is associated with amnesia. However, it remains unclear whether ‘memory for recent eating’ plays a significant role in neurologically intact humans. In this study we isolated the extent to which memory for a recently consumed meal influences hunger and fullness over a three-hour period. Before lunch, half of our volunteers were shown 300 ml of soup and half were shown 500 ml. Orthogonal to this, half consumed 300 ml and half consumed 500 ml. This process yielded four separate groups (25 volunteers in each). Independent manipulation of the ‘actual’ and ‘perceived’ soup portion was achieved using a computer-controlled peristaltic pump. This was designed to either refill or draw soup from a soup bowl in a covert manner. Immediately after lunch, self-reported hunger was influenced by the actual and not the perceived amount of soup consumed. However, two and three hours after meal termination this pattern was reversed - hunger was predicted by the perceived amount and not the actual amount. Participants who thought they had consumed the larger 500-ml portion reported significantly less hunger. This was also associated with an increase in the ‘expected satiation’ of the soup 24-hours later. For the first time, this manipulation exposes the independent and important contribution of memory processes to satiety. Opportunities exist to capitalise on this finding to reduce energy intake in humans.
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