Predictable and host-species specific humanization of the gut microbiota in captive primates.
Predictable and host-species specific humanization of the gut microbiota in captive primates.
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DOI：
10.1111/mec.15994
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发表时间：
2021-08
影响因子：
4.9
通讯作者：
Moeller AH
中科院分区：
文献类型：
--
作者：
Houtz JL;Sanders JG;Denice A;Moeller AH
人类和非人类灵长类动物（NHP）拥有复杂的肠道微生物群落，影响表型和健身。野生NHP的肠道微生物谱系反映了其宿主的系统发育历史，并且在组成上与人类的肠道微生物谱系不同，但在圈养条件下，NHP的内源性肠道微生物谱系可能丢失或被人类中发现的谱系取代。尽管其对胃肠道功能障碍的潜在贡献，但肠道微生物群的这种人源化尚未在圈养NHP物种中进行系统研究。在这里，我们通过对猿和猴的野生和圈养种群进行充分采样的比较表明，通过圈养而人性化的肠道微生物群的比例在NHP物种之间存在显着差异，但在相同NHP物种的圈养种群之间具有显着的可重复性。同种圈养种群显示出显着大于预期的重叠，在细菌16S rRNA基因的变异，圈养和野生之间的差异丰富的集。这种重叠是显而易见的，即使在圈养种群居住在不同的大陆，但从来没有观察到异种圈养种群之间。此外，我们开发了一种方法，该方法结合了人类肠道微生物群数据，以基于NHP的肠道微生物分支在圈养中丢失或被人类中发现的分支取代的倾向来对NHP的肠道微生物分支进行排名。相对较少的微生物属在不同的圈养宿主物种中表现出可重复的人源化程度，但大多数微生物属在圈养种群的同种对中可重复地人源化或从野外保留。这些结果表明，圈养NHP的肠道微生物群落显示出可预测的，宿主物种特异性的圈养反应。
Humans and nonhuman primates (NHPs) harbor complex gut microbial communities that affect phenotypes and fitness. The gut microbiotas of wild NHPs reflect their hosts’ phylogenetic histories and are compositionally distinct from those of humans, but in captivity the endogenous gut microbial lineages of NHPs can be lost or replaced by lineages found in humans. Despite its potential contributions to gastrointestinal dysfunction, this humanization of the gut microbiota has not been investigated systematically across captive NHP species. Here, we show through comparisons of well-sampled wild and captive populations of apes and monkeys that the fraction of the gut microbiota humanized by captivity varies significantly between NHP species but is remarkably reproducible between captive populations of the same NHP species. Conspecific captive populations displayed significantly greater than expected overlap in the sets of bacterial 16S rRNA gene variants that were differentially abundant between captivity and the wild. This overlap was evident even between captive populations residing on different continents but was never observed between heterospecific captive populations. In addition, we developed an approach incorporating human gut microbiota data to rank NHPs’ gut microbial clades based on the propensity of their lineages to be lost or replaced in captivity by lineages found in humans. Relatively few microbial genera displayed reproducible degrees of humanization in different captive host species, but most microbial genera were reproducibly humanized or retained from the wild in conspecific pairs of captive populations. These results demonstrate that the gut microbiotas of captive NHPs display predictable, host-species specific responses to captivity.
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影响因子：
2.6
作者：
McKenzie VJ;Song SJ;Delsuc F;Prest TL;Oliverio AM;Korpita TM;Alexiev A;Amato KR;Metcalf JL;Kowalewski M;Avenant NL;Link A;Di Fiore A;Seguin-Orlando A;Feh C;Orlando L;Mendelson JR;Sanders J;Knight R
通讯作者：
Knight R
影响因子：
6.4
作者：
McDonald D;Hyde E;Debelius JW;Morton JT;Gonzalez A;Ackermann G;Aksenov AA;Behsaz B;Brennan C;Chen Y;DeRight Goldasich L;Dorrestein PC;Dunn RR;Fahimipour AK;Gaffney J;Gilbert JA;Gogul G;Green JL;Hugenholtz P;Humphrey G;Huttenhower C;Jackson MA;Janssen S;Jeste DV;Jiang L;Kelley ST;Knights D;Kosciolek T;Ladau J;Leach J;Marotz C;Meleshko D;Melnik AV;Metcalf JL;Mohimani H;Montassier E;Navas-Molina J;Nguyen TT;Peddada S;Pevzner P;Pollard KS;Rahnavard G;Robbins-Pianka A;Sangwan N;Shorenstein J;Smarr L;Song SJ;Spector T;Swafford AD;Thackray VG;Thompson LR;Tripathi A;Vázquez-Baeza Y;Vrbanac A;Wischmeyer P;Wolfe E;Zhu Q;American Gut Consortium;Knight R
通讯作者：
Knight R
影响因子：
4.8
作者：
DICE, LR
通讯作者：
DICE, LR
健康，慢病毒感染和慢性小肠结肠炎的猕猴肠道微生物组。
影响因子：
6.7
作者：
McKenna P;Hoffmann C;Minkah N;Aye PP;Lackner A;Liu Z;Lozupone CA;Hamady M;Knight R;Bushman FD
通讯作者：
Bushman FD
影响因子：
9.8
作者：
Ochman H;Worobey M;Kuo CH;Ndjango JB;Peeters M;Hahn BH;Hugenholtz P
通讯作者：
Hugenholtz P