Population structure of the malaria vector Anopheles moucheti in the equatorial forest region of Africa.
Population structure of the malaria vector Anopheles moucheti in the equatorial forest region of Africa.
复制标题
非洲赤道森林地区的疟疾载体围绕菌群的种群结构。
DOI：
10.1186/1475-2875-7-120
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发表时间：
2008-07-04
期刊：
影响因子：
3
通讯作者：
Simard, Frederic
中科院分区：
文献类型：
--
作者：
Antonio-Nkondjio, Christophe;Ndo, Cyrille;Kengne, Pierre;Mukwaya, Louis;Awono-Ambene, Parfait;Fontenille, Didier;Simard, Frederic
莫氏按蚊是非洲森林地区的一种主要疟疾病媒。然而，尽管它在流行病学方面发挥着重要作用，但人们对它的了解仍然很少，研究也不够。在这里，遗传分化水平的估计之间的不同A。在中非的整个分布范围内取样的moucheti种群。在喀麦隆、刚果民主共和国和乌干达维多利亚湖上的一个岛屿采集的蚊子样本中，比较了10个微卫星标记的多态性。微卫星数据被用来估计种群内的遗传多样性，它们的相对长期有效种群规模，以及它们之间的遗传分化水平。所有采集于查卡拉库库（刚果民主共和国）的标本均被鉴定为A. M. bervoetsi，而其它样品由A. M.穆切蒂在所有A. M. moucheti样本中扩增出6个位点，而A. M.贝弗茨酒等位基因丰富度和杂合性高，为所有群体，除了乌干达和A。M.贝弗茨酒在A. M. bervoetsi和A. M. moucheti样本以及A. M. moucheti和大陆人口。大陆人群之间的距离明显隔离。高水平的遗传分化支持A. M. bervoetsi为一个全种，命名为A.贝弗茨酒距离隔离是引起中国大陆种群间分化的主要因素。M.穆切蒂维多利亚湖岛屿上存在遗传和地理上相互隔离的种群，可作为评价创新性病媒控制战略的相关实地地点。
Anopheles moucheti is a major malaria vector in forested areas of Africa. However, despite its important epidemiological role, it remains poorly known and insufficiently studied. Here, levels of genetic differentiation were estimated between different A. moucheti populations sampled throughout its distribution range in Central Africa. Polymorphism at ten microsatellite markers was compared in mosquitoes sampled in Cameroon, the Democratic Republic of Congo and an island on Lake Victoria in Uganda. Microsatellite data were used to estimate genetic diversity within populations, their relative long-term effective population size, and the level of genetic differentiation between them. All specimens collected in Tsakalakuku (Democratic Republic of Congo) were identified as A. m. bervoetsi while other samples consisted of A. m. moucheti. Successful amplification was obtained at all microsatellite loci within all A. m. moucheti samples while only six loci amplified in A. m. bervoetsi. Allelic richness and heterozygosity were high for all populations except the island population of Uganda and A. m. bervoetsi. High levels of genetic differentiation were recorded between A. m. bervoetsi and each A. m. moucheti sample as well as between the island population of A. m. moucheti and mainland populations. Significant isolation by distance was evidenced between mainland populations. High levels of genetic differentiation supports complete speciation of A. m. bervoetsi which should henceforth be recognized as a full species and named A. bervoetsi. Isolation by distance is the main force driving differentiation between mainland populations of A. m. moucheti. Genetically and geographically isolated populations exist on Lake Victoria islands, which might serve as relevant field sites for evaluation of innovative vector control strategies.
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影响因子：
64.8
作者：
BOWCOCK, AM;RUIZLINARES, A;CAVALLISFORZA, LL
通讯作者：
CAVALLISFORZA, LL
影响因子：
2.1
作者：
Antonio-Nkondjio, C;Awono-Ambene, P;Fontenille, D
通讯作者：
Fontenille, D
影响因子：
2.7
作者：
Antonio-Nkondjio, Christophe;Ndo, Cyrille;Simard, Frederic
通讯作者：
Simard, Frederic
影响因子：
9.2
作者：
Cohen, Barney
通讯作者：
Cohen, Barney
影响因子：
3.9
作者：
IRWIN, DM;KOCHER, TD;WILSON, AC
通讯作者：
WILSON, AC