ViRBase: a resource for virus-host ncRNA-associated interactions.

ViRBase: a resource for virus-host ncRNA-associated interactions.
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DOI:
10.1093/nar/gku903
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发表时间:
2015-01
影响因子:
14.9
通讯作者:
Wang D
Wang D
中科院分区:
生物学2区
文献类型:
--
作者:
Li Y;Wang C;Miao Z;Bi X;Wu D;Jin N;Wang L;Wu H;Qian K;Li C;Zhang T;Zhang C;Yi Y;Lai H;Hu Y;Cheng L;Leung KS;Li X;Zhang F;Li K;Li X;Wang D

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越来越多的证据表明,各种非编码RNA(NcRNAs)在病毒感染中起着至关重要的作用。病毒可以使用不同的ncRNAs来操纵细胞和病毒基因的表达,以建立有利于病毒生命周期完成的宿主环境。许多宿主细胞的ncRNAs也可以直接或间接地影响病毒的复制,甚至靶向病毒基因组。ViRBase(http://www.rna-society.org/virbase))旨在为科学界提供有效浏览和可视化病毒感染中与宿主ncRNA相关的相互作用和相互作用网络的资源。当前版本的ViRBase记录了12 000多种病毒和细胞内ncRNA相关的病毒-病毒、病毒-宿主、宿主-病毒和宿主-宿主的相互作用,涉及60多种病毒和20多种宿主之间的460多个非冗余ncRNA和4400个蛋白质编码基因。用户可以查询、浏览和操作这些与病毒宿主ncRNA相关的交互作用。ViRBase将有助于揭示病毒感染中细胞病毒-宿主ncRNA相关相互作用网络的一般组织原则。
Increasing evidence reveals that diverse non-coding RNAs (ncRNAs) play critically important roles in viral infection. Viruses can use diverse ncRNAs to manipulate both cellular and viral gene expression to establish a host environment conducive to the completion of the viral life cycle. Many host cellular ncRNAs can also directly or indirectly influence viral replication and even target virus genomes. ViRBase (http://www.rna-society.org/virbase) aims to provide the scientific community with a resource for efficient browsing and visualization of virus-host ncRNA-associated interactions and interaction networks in viral infection. The current version of ViRBase documents more than 12 000 viral and cellular ncRNA-associated virus–virus, virus–host, host–virus and host–host interactions involving more than 460 non-redundant ncRNAs and 4400 protein-coding genes from between more than 60 viruses and 20 hosts. Users can query, browse and manipulate these virus–host ncRNA-associated interactions. ViRBase will be of help in uncovering the generic organizing principles of cellular virus–host ncRNA-associated interaction networks in viral infection.
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发表时间: 2011-01
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