Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making.
Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making.
复制标题
人类知觉决策过程中纹状体中的亚秒多巴胺和5-羟色胺信号。
DOI：
10.1016/j.neuron.2020.09.015
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发表时间：
2020-12-09
期刊：
影响因子：
16.2
通讯作者：
Montague PR
中科院分区：
文献类型：
--
作者：
Bang D;Kishida KT;Lohrenz T;White JP;Laxton AW;Tatter SB;Fleming SM;Montague PR
最近的动物研究表明，多巴胺和血清素，传统上与食欲和厌恶过程有关的神经调节剂，也参与了感官推理和基于这种推理的决定。我们在人类中测试了这一假设，通过监测亚秒纹状体多巴胺和5-羟色胺信号在视觉运动辨别任务，分离感官的不确定性，决策困难的析因设计。尾状核记录（n = 4）揭示了多尺度编码：在三名参与者中，5-羟色胺跟踪感觉不确定性，并且在一名参与者中，多巴胺和5-羟色胺都跟踪偏离我们的析因设计中预期的试验转换。壳核记录（n = 1）支持尾状核和壳核（灵长类动物特有的纹状体分区）之间的认知-动作分离，多巴胺和5-羟色胺跟踪决策时间。这些在人类大脑中的首次观察揭示了亚秒多巴胺和5-羟色胺信号在认知和行动的非奖励方面的作用。多巴胺和5-羟色胺在清醒时的决策过程中在人类纹状体中被测量。5-羟色胺跟踪尾状核中的感觉不确定性。多巴胺和5-羟色胺跟踪尾状核中的感觉统计。Bang，Kishida et al.在人类大脑中显示，这些神经调质也在认知和行为的非奖励方面发挥作用，包括快速感知决策过程和行动。
Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive and aversive processes, are also involved in sensory inference and decisions based on such inference. We tested this hypothesis in humans by monitoring sub-second striatal dopamine and serotonin signaling during a visual motion discrimination task that separates sensory uncertainty from decision difficulty in a factorial design. Caudate nucleus recordings (n = 4) revealed multi-scale encoding: in three participants, serotonin tracked sensory uncertainty, and, in one participant, both dopamine and serotonin tracked deviations from expected trial transitions within our factorial design. Putamen recordings (n = 1) supported a cognition-action separation between caudate nucleus and putamen—a striatal sub-division unique to primates—with both dopamine and serotonin tracking decision times. These first-of-their-kind observations in the human brain reveal a role for sub-second dopamine and serotonin signaling in non-reward-based aspects of cognition and action. Dopamine and serotonin are measured in human striatum during awake decision-making Serotonin tracks sensory uncertainty in caudate nucleus Dopamine and serotonin track sensory statistics in caudate nucleus Dopamine and serotonin track decision times in putamen Dopamine and serotonin have traditionally been linked to reward processing. Bang, Kishida et al. show in the human brain that these neuromodulators also play a role in non-reward-based aspects of cognition and behavior, including rapid perceptual decision processes and action.
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DOI：
10.1073/pnas.1800795115
发表时间：
2018-06-05
影响因子：
11.1
作者：
Bang, Dan;Fleming, Stephen M.
通讯作者：
Fleming, Stephen M.
影响因子：
7.7
作者：
Doi, Takahiro;Fan, Yunshu;Ding, Long
通讯作者：
Ding, Long
影响因子：
48
作者：
Clark, Jeremy J.;Sandberg, Stefan G.;Wanat, Matthew J.;Gan, Jerylin O.;Horne, Eric A.;Hart, Andrew S.;Akers, Christina A.;Parker, Jones G.;Willuhn, Ingo;Martinez, Vicente;Evans, Scott B.;Stella, Nephi;Phillips, Paul E. M.
通讯作者：
Phillips, Paul E. M.
影响因子：
8.8
作者：
Gantz SC;Levitt ES;Llamosas N;Neve KA;Williams JT
通讯作者：
Williams JT
DOI：
10.1038/npp.2012.75
发表时间：
2012-09
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
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作者：
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