Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring.
Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring.
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DOI：
10.1038/tp.2016.276
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发表时间：
2017-01-17
影响因子：
6.8
通讯作者：
Castellanos FX
中科院分区：
文献类型：
--
作者：
Yan CG;Rincón-Cortés M;Raineki C;Sarro E;Colcombe S;Guilfoyle DN;Yang Z;Gerum S;Biswal BB;Milham MP;Sullivan RM;Castellanos FX
照顾者虐待会诱发晚年精神病理的脆弱性。临床和临床前证据表明，前额叶和边缘电路的变化是这种易感性的基础。我们使用大鼠母性虐待模型和人类的静息状态功能磁共振成像（R-fMRI）方法来研究这个问题。从出生后（PN）第8天到第12天，在不充足或不充足的床上筑巢的母鼠饲养幼鼠，并在青春期（PN45）和成年早期（PN60）对幼鼠进行情感相关行为（强迫游泳、蔗糖偏好和社会互动）的行为评估。两个年龄的患者均在轻度麻醉下进行R-fMRI。没有足够的床上用品（即虐待）的后代表现出持久的消极情感行为。在对照组中，杏仁核-前额叶皮层（PFC）功能连接从青春期到成年期显著增加，但在虐待动物中没有。我们计算了低频波动的分数幅度（fALFF），这是一种内在大脑活动的指数，发现在对照组中，内侧前额叶皮层和前扣带皮层（MPFC/ACC）的fALFF随着年龄的增长而显著增加，但在青春期和成年期受到虐待的动物中，fALFF保持不变。我们使用基于种子的分析来探索该区域和整个大脑之间功能连接的变化。与对照组相比，受虐待的动物在两个年龄阶段都表现出MPFC/ACC和左尾状核/壳核之间的功能连接减少。MPFC/ACC与右尾状核/壳核之间的功能连通性显示出年龄组的相互作用：对照组减少，但虐待动物增加。这些数据表明，虐待诱发精神病理易感性，并与影响调节的前额叶和皮层下回路的不同发育轨迹有关。
Caregiver maltreatment induces vulnerability to later-life psychopathology. Clinical and preclinical evidence suggest changes in prefrontal and limbic circuitry underlie this susceptibility. We examined this question using a rat model of maternal maltreatment and methods translated from humans, resting-state functional magnetic resonance imaging (R-fMRI). Rat pups were reared by mothers provided with insufficient or abundant bedding for nest building from postnatal (PN) days 8 to 12 and underwent behavioral assessments of affect-related behaviors (forced swim, sucrose preference and social interaction) in adolescence (PN45) and early adulthood (PN60). R-fMRI sessions were conducted under light anesthesia at both ages. Offspring reared with insufficient bedding (that is, maltreated) displayed enduring negative affective behaviors. Amygdala-prefrontal cortex (PFC) functional connectivity increased significantly from adolescence to adulthood in controls, but not in maltreated animals. We computed the fractional amplitude of low-frequency fluctuations (fALFF), an index of intrinsic brain activity, and found that fALFF in medial prefrontal cortex and anterior cingulate cortex (MPFC/ACC) increased significantly with age in controls but remained unchanged in maltreated animals during adolescence and adulthood. We used a seed-based analysis to explore changes in functional connectivity between this region and the whole brain. Compared with controls, maltreated animals demonstrated reduced functional connectivity between MPFC/ACC and left caudate/putamen across both ages. Functional connectivity between MPFC/ACC and right caudate/putamen showed a group by age interaction: decreased in controls but increased in maltreated animals. These data suggest that maltreatment induces vulnerability to psychopathology and is associated with differential developmental trajectories of prefrontal and subcortical circuits underlying affect regulation.
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影响因子：
3.5
作者：
Drury SS;Sánchez MM;Gonzalez A
通讯作者：
Gonzalez A
DOI：
10.1073/pnas.1307893110
发表时间：
2013-09-24
影响因子：
11.1
作者：
Gee, Dylan G.;Gabard-Durnam, Laurel J.;Tottenham, Nim
通讯作者：
Tottenham, Nim
DOI：
10.1111/jcpp.12409
发表时间：
2015-11
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Graham AM;Pfeifer JH;Fisher PA;Carpenter S;Fair DA
通讯作者：
Fair DA
影响因子：
3.3
作者：
Goff B;Gee DG;Telzer EH;Humphreys KL;Gabard-Durnam L;Flannery J;Tottenham N
通讯作者：
Tottenham N
影响因子：
3
作者：
Boulanger-Bertolus, Julie;Hegoburu, Chloe;Mouly, Anne-Marie
通讯作者：
Mouly, Anne-Marie