The neurobiology of self-knowledge in depressed and self-injurious youth.
The neurobiology of self-knowledge in depressed and self-injurious youth.
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DOI：
10.1016/j.pscychresns.2016.06.015
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发表时间：
2016-08-30
期刊：
影响因子：
--
通讯作者：
Pfeifer JH
中科院分区：
文献类型：
--
作者：
Quevedo K;Martin J;Scott H;Smyda G;Pfeifer JH
在临床转诊的青少年中，关于非自杀性自我损伤(NSSI)的神经生物学基础的信息有限。然而，与NSSI相关的人际关系紊乱和自我处理障碍的突出表明，社会过程的神经基础是一个需要进一步研究的关键领域。将123名青少年(男=14.75岁，SD=1.64)分为三组：NSSI加抑郁诊断组(NSSI)、单纯抑郁组(DEP)和健康对照组(HC)。在扫描仪中，参与者通过直接(自己的)和间接(母亲、最好的朋友或同学的)关于自我特征的观点来完成人际自我处理任务。在所有角度上，NSSI在边缘区域、前后部皮质中线结构的BOLD激活高于DEP和HC，而HC在吻侧、额极和枕叶皮质的激活高于NSSI和DEP青年。此外，NSSI青少年在接受母亲视角时，在杏仁核、海马体、副海马体和梭状回表现出更高的反应，这与NSSI组中母亲对青少年情绪困扰的支持的自我报告呈负相关。从同学的角度来看，NSSI青少年在间接自我加工过程中也产生了更大的楔前和后扣带皮质活动。研究结果表明，在抑郁的青少年中，自我和情绪处理的中断以及冲突的社会关系在NSSI的神经生物学中起到了作用。
There is limited information regarding the neurobiology underlying non-suicidal self-injury (NSSI) in clinically-referred youth. However, the salience of disturbed interpersonal relationships and disrupted self-processing associated with NSSI suggests the neural basis of social processes as a key area for additional study. Adolescent participants (N=123; M=14.75 years, SD=1.64) were divided into three groups: NSSI plus depression diagnosis (NSSI), depression only (DEP), healthy controls (HC). In the scanner, participants completed an Interpersonal Self-Processing task by taking direct (own) and indirect (mothers’, best friends’, or classmates’) perspectives regarding self-characteristics. Across all perspectives, NSSI showed higher BOLD activation in limbic areas, and anterior and posterior cortical midline structures versus DEP and HC, while HC showed greater activity in rostrolateral, frontal pole and occipital cortex than NSSI and DEP youth. Moreover, NSSI youth showed heightened responses in amygdala, hippocampus, parahippocampus, and fusiform when taking their mothers’ perspective, which were negatively correlated with self-reports of the mother’s support of adolescents’ emotional distress in the NSSI group. NSSI youth also yielded greater precuneus and posterior cingulate cortex activity during indirect self-processing from their classmates’ perspective. Findings suggest a role for disruptions in self- and emotion-processing, and conflicted social relationships in the neurobiology of NSSI among depressed adolescents.
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