Expression levels of induced sputum IL-8 and IL-10 and drug intervention effects in patients with acute exacerbated COPD complicated with chronic cor pulmonale at high altitude.
Expression levels of induced sputum IL-8 and IL-10 and drug intervention effects in patients with acute exacerbated COPD complicated with chronic cor pulmonale at high altitude.
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DOI：
10.3892/etm.2013.1192
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发表时间：
2013-09
影响因子：
2.7
通讯作者：
Liu R
中科院分区：
文献类型：
--
作者：
Feng E;Wan R;Yang S;Yan Z;Wang S;He W;Zhang Y;Yin H;Chen Z;Liu R
本研究旨在评估高原地区急性加重型慢性阻塞性肺疾病（AECOPD）并发慢性肺心病（CCP）患者诱导痰白细胞介素（IL）-8和IL-10水平的表达水平，并评价吸入皮质类固醇（ICS）和β2肾上腺素受体激动剂对该疾病的干预效果。将186例AECOPD合并CCP患者随机分为3组，每组62例。两个治疗组中，A组采用沙美特罗/氟替卡松（分别为50μg/250μg）气道吸入，每日两次，B组采用布地奈德（1mg）喷雾吸入，每日两次。常规治疗组(C组)仅接受常规治疗。入院时及治疗后两周稳定期检查诱导痰中IL-8、IL-10水平以及预测一秒用力呼气量百分比（FEV1%pred）、动脉血氧分压（PaO2）和动脉血二氧化碳分压（PaCO2）。四十名健康志愿者作为对照组（D组）。与D组相比，治疗前3个COPD组IL-8诱导痰水平和PaCO2显着升高，而IL-10、FEV1%pred和PaO2水平显着降低。治疗后，3个治疗组诱导痰IL-8水平和PaCO2均较治疗前显着降低，而诱导痰IL-10水平、FEV1%pred和PaO2均较治疗前显着升高（均P<0.01）。三组治疗后参数差异有统计学意义（P<0.01）。结果表明IL-8和IL-10参与了AECOPD并发CCP的气道炎症。 ICS 治疗被证明是减少 IL-8 局部表达并增加 IL-10 局部表达的成功方法；然而，ICS联合长效β2-肾上腺素受体激动剂（LABA）对于高原AECOPD并发CCP患者比单独使用ICS更有效。
The aim of this study was to assess the expression levels of induced sputum interleukin (IL)-8 and IL-10 levels in patients with acute exacerbated chronic obstructive pulmonary disease (AECOPD) complicated with chronic cor pulmonale (CCP) at high altitude, and to evaluate the intervention effects of an inhaled corticosteroid (ICS) and a β2-adrenoceptor agonist in this disease. A total of 186 patients with AECOPD complicated with CCP were randomly divided into three groups, with 62 cases in each. With regard to the two treatment groups, group A was treated with salmeterol/fluticasone (50 μg/250 μg, respectively) by airway inhalation twice daily, while group B received budesonide (1 mg) as a spray inhalation, twice daily. The routine treatment group (group C) received only routine treatment. The levels of IL-8 and IL-10 in the induced sputum and the predicted percentage of forced expiratory volume in one second (FEV1%pred), partial pressure of oxygen in arterial blood (PaO2) and partial pressure of carbon dioxide in arterial blood (PaCO2) were examined on admission and at a stable stage two weeks following treatment. Forty healthy volunteers served as a control group (group D). Compared with group D values, the IL-8 induced sputum level and the PaCO2 were significantly increased, while the level of IL-10, FEV1%pred and the PaO2 were markedly decreased in the three COPD groups prior to treatment. Following treatment, the induced sputum IL-8 level and the PaCO2 were significantly decreased, while the induced sputum IL-10 level, FEV1%pred and the PaO2 were markedly increased in the three treatment groups compared with the values pre-therapy (all P<0.01). The post-treatment parameters were significantly different among the three groups (P<0.01). The results indicate that IL-8 and IL-10 are involved in the airway inflammation of AECOPD complicated by CCP. Treatment with an ICS was demonstrated to be a successful method of reducing the local expression of IL-8 and increasing the local expression of IL-10; however, ICS combined with a long-acting β2-adrenoceptor agonist (LABA) was more effective than the sole administration of ICS in patients with AECOPD complicated by CCP at high altitude.
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DOI：
10.1165/ajrcmb.27.1.4766
发表时间：
2002-07-01
影响因子：
6.4
作者：
Oudin, S;Pugin, M
通讯作者：
Pugin, M
影响因子：
5.8
作者：
Parr DG;White AJ;Bayley DL;Guest PJ;Stockley RA
通讯作者：
Stockley RA
影响因子：
10
作者：
Bourbeau, Jean;Christodoulopoulos, Pota;Hamid, Qutayba
通讯作者：
Hamid, Qutayba
影响因子：
2.1
作者：
Burgess, JL;Nanson, CJ;Lantz, RC
通讯作者：
Lantz, RC
影响因子：
24.3
作者：
Gong, MN;Thompson, BT;Christiani, DC
通讯作者：
Christiani, DC