Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study.
Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study.
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DOI：
10.1186/1465-9921-7-136
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发表时间：
2006-11-18
影响因子：
5.8
通讯作者：
Stockley RA
中科院分区：
文献类型：
--
作者：
Parr DG;White AJ;Bayley DL;Guest PJ;Stockley RA
炎症被认为是COPD的主要致病因素，但目前的认识所依据的证据并不能区分因果关系，也没有单一的机制可以解释复杂的病理学。我们对COPD受试者进行了一项前瞻性纵向研究，将基线时的痰液炎症标志物与随后的疾病进展相关。一个队列的56例慢性支气管炎患者的特点是在稳定状态的基线和间隔四年后，使用生理措施和CT密度测定。在一个亚组（n = 38）中，在基线时从自发产生的痰中定量气道炎症的痰标志物，并且炎症严重程度与随后的疾病进展相关。生理和CT测量表明整个组的疾病进展。在亚组中，痰液髓过氧化物酶与FEV 1下降相关（rs =-0.344，p = 0.019，n = 37）。LTB 4和白蛋白渗漏与TLCO下降相关（分别为rs =-0.310，p = 0.033，rs =-0.401，p = 0.008，n = 35），IL-8与肺密度指数进展相关（rs =-0.464，p = 0.005，n = 38）。这些数据支持嗜酸性炎症在COPD发病机制中的主要致病作用，并表明痰液炎症标志物的测量在临床实践中可能具有预测作用。
Inflammation is considered to be of primary pathogenic importance in COPD but the evidence on which current understanding is based does not distinguish between cause and effect, and no single mechanism can account for the complex pathology. We performed a prospective longitudinal study of subjects with COPD that related markers of sputum inflammation at baseline to subsequent disease progression. A cohort of 56 patients with chronic bronchitis was characterized in the stable state at baseline and after an interval of four years, using physiological measures and CT densitometry. Sputum markers of airway inflammation were quantified at baseline from spontaneously produced sputum in a sub-group (n = 38), and inflammation severity was related to subsequent disease progression. Physiological and CT measures indicated disease progression in the whole group. In the sub-group, sputum myeloperoxidase correlated with decline in FEV1 (rs = -0.344, p = 0.019, n = 37). LTB4 and albumin leakage correlated with TLCO decline (rs = -0.310, p = 0.033, rs = -0.401, p = 0.008, respectively, n = 35) and IL-8 correlated with progression of lung densitometric indices (rs = -0.464, p = 0.005, n = 38). The data support a principal causative role for neutrophilic inflammation in the pathogenesis of COPD and suggest that the measurement of sputum inflammatory markers may have a predictive role in clinical practice.
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影响因子：
15.9
作者：
OGILVIE, CM;FORSTER, RE;MORTON, JW
通讯作者：
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