Structural brain development: A review of methodological approaches and best practices.

Structural brain development: A review of methodological approaches and best practices.
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DOI:
10.1016/j.dcn.2017.11.008
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发表时间:
2018-10
影响因子:
4.7
通讯作者:
Whittle S
Whittle S
中科院分区:
医学1区
文献类型:
--
作者:
Vijayakumar N;Mills KL;Alexander-Bloch A;Tamnes CK;Whittle S

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神经影像技术和统计建模能力的不断进步提高了我们对儿童和青少年大脑结构发育的了解。虽然这让我们对大脑发育有了越来越细致的了解,但该领域仍然受到不一致的研究结果的困扰。这篇综述强调了现有的关于儿童和青春期大脑结构发育的纵向磁共振成像(MRI)研究的方法学多样性,并讨论了这种差异如何导致文献中的不一致。我们讨论了研究过程中多个决策点的方法选择的影响,从研究设计和样本选择到图像处理和统计分析。我们还强调了对不同方法论考虑因素进行实证检验的程度,提请人们注意将从未来研究中受益的特定领域。在适当的情况下,我们建议该领域采用某些有益的最佳实践,包括提高报告方法的完整性和透明度,以便最终对规范的儿童和青少年大脑发育形成准确和详细的理解。
Continued advances in neuroimaging technologies and statistical modelling capabilities have improved our knowledge of structural brain development in children and adolescents. While this has provided an increasingly nuanced understanding of brain development, the field is still plagued by inconsistent findings. This review highlights the methodological diversity in existing longitudinal magnetic resonance imaging (MRI) studies on structural brain development during childhood and adolescence, and addresses how such variation might contribute to inconsistencies in the literature. We discuss the impact of method choices at multiple decision points across the research process, from study design and sample selection, to image processing and statistical analysis. We also highlight the extent to which different methodological considerations have been empirically examined, drawing attention to specific areas that would benefit from future investigation. Where appropriate, we recommend certain best practices that would be beneficial for the field to adopt, including greater completeness and transparency in reporting methods, in order to ultimately develop an accurate and detailed understanding of normative child and adolescent brain development.
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