Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities.
Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities.
复制标题
DOI：
10.1093/sleep/zsaa281
复制
发表时间：
2021-05-14
期刊：
影响因子：
5.6
通讯作者：
Klerman EB
中科院分区：
文献类型：
--
作者：
Duffy JF;Abbott SM;Burgess HJ;Crowley SJ;Emens JS;Epstein LJ;Gamble KL;Hasler BP;Kristo DA;Malkani RG;Rahman SA;Thomas SJ;Wyatt JK;Zee PC;Klerman EB
这份白色论文介绍了由睡眠研究学会（SRS）和生物节律研究学会（SRBR）共同主办的研讨会的结果，该研讨会的目标是将睡眠临床医生和睡眠与昼夜节律研究人员聚集在一起，以确定昼夜节律睡眠-觉醒障碍（CRSWD）诊断和治疗方面的现有差距以及高优先级研究领域。CRSWD是由昼夜节律计时系统的改变、其夹带机制或内源性昼夜节律与外部环境的失调引起的一类独特的睡眠障碍。在这些疾病中，主要睡眠事件的时间比期望的要早或晚，从一天到一天的不规则，和/或睡眠发生在错误的昼夜节律时间。虽然有不完整和不充分的流行率数据，但CRSWD可能影响美国至少80万人，甚至可能多达300万人，如果将轮班工作障碍和时差综合症包括在内，则还有数百万人受到影响。SRS倡导工作组已将CRSWD确定为一类睡眠障碍，额外的高质量研究可能会对改善患者护理产生重大影响。参与者根据他们的专业知识被选中，并被分配到三个工作组之一：相位障碍，夹带障碍和其他。每个工作组介绍了其特定CRSWD领域的科学现状摘要，然后由所有与会者进行讨论。这些介绍和讨论的结果载于本报告。
This White Paper presents the results from a workshop cosponsored by the Sleep Research Society (SRS) and the Society for Research on Biological Rhythms (SRBR) whose goals were to bring together sleep clinicians and sleep and circadian rhythm researchers to identify existing gaps in diagnosis and treatment and areas of high-priority research in circadian rhythm sleep–wake disorders (CRSWD). CRSWD are a distinct class of sleep disorders caused by alterations of the circadian time-keeping system, its entrainment mechanisms, or a misalignment of the endogenous circadian rhythm and the external environment. In these disorders, the timing of the primary sleep episode is either earlier or later than desired, irregular from day-to-day, and/or sleep occurs at the wrong circadian time. While there are incomplete and insufficient prevalence data, CRSWD likely affect at least 800,000 and perhaps as many as 3 million individuals in the United States, and if Shift Work Disorder and Jet Lag are included, then many millions more are impacted. The SRS Advocacy Taskforce has identified CRSWD as a class of sleep disorders for which additional high-quality research could have a significant impact to improve patient care. Participants were selected for their expertise and were assigned to one of three working groups: Phase Disorders, Entrainment Disorders, and Other. Each working group presented a summary of the current state of the science for their specific CRSWD area, followed by discussion from all participants. The outcome of those presentations and discussions are presented here.
登录
查看更多内容
影响因子：
5.6
作者：
Curtis, Brian John;Ashbrook, Liza H.;Jones, Christopher R.
通讯作者：
Jones, Christopher R.
影响因子：
9.9
作者：
Boivin, DB;James, FO;Chalk, C
通讯作者：
Chalk, C
光，褪黑激素以及其他褪黑激素激动剂对人昼夜生理学的影响。
影响因子：
2.8
作者：
Emens JS;Burgess HJ
通讯作者：
Burgess HJ
影响因子：
5.6
作者：
Cheng, Philip;Walch, Olivia;Drake, Christopher L.
通讯作者：
Drake, Christopher L.
影响因子：
9.9
作者：
Ayalon, L.;Borodkin, K.;Dagan, Y.
通讯作者：
Dagan, Y.