Transmission Cycle of Tick-Borne Infections and Co-Infections, Animal Models and Diseases.
Transmission Cycle of Tick-Borne Infections and Co-Infections, Animal Models and Diseases.
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DOI：
10.3390/pathogens11111309
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发表时间：
2022-11-08
期刊：
影响因子：
--
通讯作者：
Parveen N
中科院分区：
文献类型：
--
作者：
Rocha SC;Velásquez CV;Aquib A;Al-Nazal A;Parveen N
蜱传病原体，如伯氏疏螺旋体、巴贝斯虫、无形体、立克次体和埃利希体，在美国和欧洲的野生动物、雀形目动物以及家畜和农场动物中广泛存在。这些病原体的传播是由受感染的蜱虫在吸血、食肉和野生动物叮咬时传播的，而人类可能被受感染的蜱虫叮咬、输血以及在某些情况下先天感染。宿主在维持病原体在自然界中发挥重要作用，并促进单个病原体或多种病原体同时通过蜱传播给人类。蜱传播的合并感染最早在20世纪80年代在白足鼠中被报道，白足鼠是美国最主要的致病生物宿主，它们现在正成为公共卫生的一个主要问题。为了更好地了解蜱传病原体的发病机制和揭示共存于同一宿主中的病原体之间的相互作用，各种动物感染模型被广泛使用。在这篇综述中，我们重点关注这些病原体在不同宿主中的流行情况，用于研究它们的发病机制和它们引发的宿主反应的动物模型，以了解人类疾病。我们还记录了这些病原体的流行与受感染蜱的监测研究相关。蜱传共感染与其他主题的关联，如病原体毒力因素、与疾病严重程度相关的宿主免疫反应、候选疫苗的鉴定和疾病的经济影响，也在这里简要讨论。
Tick-borne pathogens such as species of Borrelia, Babesia, Anaplasma, Rickettsia, and Ehrlichia are widespread in the United States and Europe among wildlife, in passerines as well as in domestic and farm animals. Transmission of these pathogens occurs by infected ticks during their blood meal, carnivorism, and through animal bites in wildlife, whereas humans can become infected either by an infected tick bite, through blood transfusion and in some cases, congenitally. The reservoir hosts play an important role in maintaining pathogens in nature and facilitate transmission of individual pathogens or of multiple pathogens simultaneously to humans through ticks. Tick-borne co-infections were first reported in the 1980s in white-footed mice, the most prominent reservoir host for causative organisms in the United States, and they are becoming a major concern for public health now. Various animal infection models have been used extensively to better understand pathogenesis of tick-borne pathogens and to reveal the interaction among pathogens co-existing in the same host. In this review, we focus on the prevalence of these pathogens in different reservoir hosts, animal models used to investigate their pathogenesis and host responses they trigger to understand diseases in humans. We also documented the prevalence of these pathogens as correlating with the infected ticks’ surveillance studies. The association of tick-borne co-infections with other topics such as pathogens virulence factors, host immune responses as they relate to diseases severity, identification of vaccine candidates, and disease economic impact are also briefly addressed here.
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影响因子：
3.4
作者：
Akoolo L;Djokic V;Rocha SC;Parveen N
通讯作者：
Parveen N
DOI：
10.4269/ajtmh.1992.47.605
发表时间：
1992-11-01
影响因子：
3.3
作者：
BARTHOLD, SW;SIDMAN, CL;SMITH, AL
通讯作者：
SMITH, AL
研究疾病严重程度在同时发生的Babesios和莱姆病的动物模型中。
影响因子：
4
作者：
Bhanot P;Parveen N
通讯作者：
Parveen N
影响因子：
3.7
作者：
Adrion ER;Aucott J;Lemke KW;Weiner JP
通讯作者：
Weiner JP
影响因子：
2.6
作者：
Allred, David R.;Al-Khedery, Basima
通讯作者：
Al-Khedery, Basima