A strategy for comparing the contributions of environmental chemicals and other risk factors to neurodevelopment of children.
A strategy for comparing the contributions of environmental chemicals and other risk factors to neurodevelopment of children.
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DOI：
10.1289/ehp.1104170
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发表时间：
2012-04
影响因子：
10.4
通讯作者：
Bellinger DC
中科院分区：
文献类型：
--
作者：
Bellinger DC
背景资料：环境化学物质对儿童神经发育的影响有时被认为不重要，因为损害的程度被认为是临床上微不足道的。这样的判断反映了未能区分个人和群体风险。风险因素对人群的影响取决于其效应大小及其分布（或发病率/患病率）。目的：其目的是制定一项战略，考虑到风险因素的分布（或发病率/患病率），以及其效应大小，以估计其对儿童神经发育的人口影响。研究方法：美国0-5岁儿童的全量表智商损失总数是根据化学品（甲基汞、有机磷农药、铅）和各种医疗条件和事件（例如，早产、创伤性脑损伤、脑肿瘤、先天性心脏病）。讨论内容：虽然分析所需的数据只有三种环境化学品（甲基汞，有机磷农药，铅），结果表明，它们对神经发育的发病率的贡献是巨大的，超过了许多非化学危险因素。结论：一种比较不同危险因素的相对贡献的方法，为确定降低儿童神经发育发病率的优先次序提供了合理的依据。
Background: The impact of environmental chemicals on children’s neurodevelopment is sometimes dismissed as unimportant because the magnitude of the impairments are considered to be clinically insignificant. Such a judgment reflects a failure to distinguish between individual and population risk. The population impact of a risk factor depends on both its effect size and its distribution (or incidence/prevalence). Objective: The objective was to develop a strategy for taking into account the distribution (or incidence/prevalence) of a risk factor, as well as its effect size, in order to estimate its population impact on neurodevelopment of children. Methods: The total numbers of Full-Scale IQ points lost among U.S. children 0–5 years of age were estimated for chemicals (methylmercury, organophosphate pesticides, lead) and a variety of medical conditions and events (e.g., preterm birth, traumatic brain injury, brain tumors, congenital heart disease). Discussion: Although the data required for the analysis were available for only three environmental chemicals (methylmercury, organophosphate pesticides, lead), the results suggest that their contributions to neurodevelopmental morbidity are substantial, exceeding those of many nonchemical risk factors. Conclusion: A method for comparing the relative contributions of different risk factors provides a rational basis for establishing priorities for reducing neurodevelopmental morbidity in children.
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作者：
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影响因子：
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作者：
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