Gut Microbiome and Its Associations With Acute and Chronic Gastrointestinal Toxicities in Cancer Patients With Pelvic Radiation Therapy: A Systematic Review.
Gut Microbiome and Its Associations With Acute and Chronic Gastrointestinal Toxicities in Cancer Patients With Pelvic Radiation Therapy: A Systematic Review.
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DOI：
10.3389/fonc.2021.745262
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发表时间：
2021
影响因子：
4.7
通讯作者：
Bruner DW
中科院分区：
文献类型：
--
作者：
Bai J;Barandouzi ZA;Rowcliffe C;Meador R;Tsementzi D;Bruner DW
盆腔放射治疗（RT）可能会影响癌症患者的肠道微生物组，并导致胃肠道（GI）毒性。这项系统性综述的目的是描述RT对肠道微生物组的影响以及接受盆腔RT治疗的患者的肠道微生物组与GI毒性之间的相关性。对PubMed、Embase和Web of Science数据库进行了检索，从最早的记录到2020年8月。文章筛选过程遵循系统性综述和荟萃分析指南的首选报告项目。使用混合方法评估工具评估每项纳入研究的方法学质量。所有研究结果均以叙述格式进行综合和呈现。纳入了13项研究。使用16 S rRNA测序方法分析粪便样品的肠道微生物组。研究中存在α和β分布的差异。不同的门，包括厚壁菌门，拟杆菌门，变形菌门，放线菌门，蓝细菌门，梭菌门，和异常球菌栖热菌。此外，与癌症治疗相关的肠道微生物组多样性和丰度的改变与盆腔毒性，特别是腹泻有关。治疗后，类杆菌丰度的增加与腹泻和放射性肠炎有关。盆腔RT可以破坏肠道微生物的多样性和丰富性。肠道微生物群失调通过改变肠道屏障功能、先天免疫和肠道修复机制，显示出与放射性肠炎的潜在关联;然而，混杂因素（如饮食）并未得到彻底解决。
Pelvic radiation therapy (RT) can impact the gut microbiome in patients with cancer and result in gastrointestinal (GI) toxicities. The purpose of this systematic review was to describe the effects of RT on the gut microbiome and the associations between the gut microbiome and GI toxicities in patients treated with pelvic RT. PubMed, Embase, and Web of Science databases were searched from their earliest records to August 2020. The articles screening process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Mixed Method Assessment Tool was used to assess the methodological quality for each included study. All study findings were synthesized and presented in narrative format. Thirteen studies were included. The gut microbiome of fecal samples was analyzed using 16S rRNA sequencing approaches. There were disparities in alpha and beta diversities that existed across the studies. Divergent results were found among various phyla, including Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Cyanobacteria, Fusobacteria, and Deinococcus-Thermus. Moreover, alteration in the gut microbiome diversity and abundance related to cancer treatment was associated with pelvic toxicities, specifically diarrhea. Following treatment, increases in the abundance of Bacteroides was associated with diarrhea and radiation enteritis. Pelvic RT can disrupt the diversity and abundance of commensal gut microorganisms. A dysbiotic gut microbiome showed a promising association with radiation enteritis through alterations of the intestinal barrier function, innate immunity, and intestinal repair mechanisms; however, confounders, such as diet, were not thoroughly addressed.
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DOI：
10.1200/edbk_323525
发表时间：
2021-03-01
期刊：
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
影响因子：
--
作者：
Dalsania, Raj M;Shah, Kevin P;Willingham, Field F
通讯作者：
Willingham, Field F
影响因子：
3.8
作者：
Bai, J.;Hu, Y.;Bruner, D. W.
通讯作者：
Bruner, D. W.
DOI：
10.1073/pnas.0504830102
发表时间：
2005-09-13
影响因子：
11.1
作者：
Crawford, PA;Gordon, JI
通讯作者：
Gordon, JI
影响因子：
2.6
作者：
Gonzalez-Mercado, Velda J.;Lim, Jean;Colon-Otero, Gerardo
通讯作者：
Colon-Otero, Gerardo
影响因子：
4.2
作者：
Lopetuso LR;Scaldaferri F;Petito V;Gasbarrini A
通讯作者：
Gasbarrini A