Commensal Clostridia: leading players in the maintenance of gut homeostasis.
Commensal Clostridia: leading players in the maintenance of gut homeostasis.
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DOI：
10.1186/1757-4749-5-23
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发表时间：
2013-08-13
期刊：
影响因子：
4.2
通讯作者：
Gasbarrini A
中科院分区：
文献类型：
--
作者：
Lopetuso LR;Scaldaferri F;Petito V;Gasbarrini A
胃肠道是一个复杂而动态的网络，其中复杂且互利的共生关系调节宿主和微生物群之间的关系，以建立和确保肠道稳态。共生梭菌由厚壁菌门中的革兰氏阳性杆状细菌组成，占肠道微生物群细菌总数的很大一部分。它们在出生后第一个月开始在母乳喂养的婴儿的肠道中定植，并在肠粘膜的特定区域中与肠细胞密切相关。这一位置使它们能够在整个生命周期中作为关键因素参与调节肠道的生理、代谢和免疫过程，通过与其他常驻微生物群体相互作用，而且还提供特定和必要的功能。本综述重点关注目前已知的共生梭状芽胞杆菌在维持整体肠道功能中的作用，以及它们对微生物群组成的不利改变（菌群失调）的潜在贡献，而微生物群组成与多种胃肠道疾病有关。共生梭菌强烈参与维持整体肠道功能。这对预防和治疗生态失调、药物疗效和毒性以及开发可调节微生物群组成的疗法（利用共生梭菌的关键作用）具有重要的转化意义，最终目标是促进肠道健康。
The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start to colonize the intestine of breastfed infants during the first month of life and populate a specific region in the intestinal mucosa in close relationship with intestinal cells. This position allows them to participate as crucial factors in modulating physiologic, metabolic and immune processes in the gut during the entire lifespan, by interacting with the other resident microbe populations, but also by providing specific and essential functions. This review focus on what is currently known regarding the role of commensal Clostridia in the maintenance of overall gut function, as well as touch on their potential contribution in the unfavorable alteration of microbiota composition (dysbiosis) that has been implicated in several gastrointestinal disorders. Commensal Clostridia are strongly involved in the maintenance of overall gut function. This leads to important translational implications in regard to the prevention and treatment of dysbiosis, to drug efficacy and toxicity, and to the development of therapies that may modulate the composition of the microflora, capitalizing on the key role of commensal Clostridia, with the end goal of promoting gut health.
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影响因子：
--
作者：
Biagi, Elena;Candela, Marco;Fairweather-Tait, Susan;Franceschi, Claudio;Brigidi, Patrizia
通讯作者：
Brigidi, Patrizia
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
2.9
作者：
Drago, Lorenzo;Toscano, Marco;Mogna, Giovanni
通讯作者：
Mogna, Giovanni
影响因子：
24.5
作者：
Ahmad, MS;Krishnan, S;Murthy, SN
通讯作者：
Murthy, SN
DOI：
10.1099/00207713-44-4-812
发表时间：
1994-10-01
期刊：
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY
影响因子：
--
作者：
COLLINS, MD;LAWSON, PA;FARROW, JAE
通讯作者：
FARROW, JAE