Neurovascular coupling in normal aging: a combined optical, ERP and fMRI study.
Neurovascular coupling in normal aging: a combined optical, ERP and fMRI study.
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DOI：
10.1016/j.neuroimage.2013.04.113
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发表时间：
2014-01-15
期刊：
影响因子：
5.7
通讯作者：
Gratton, Gabriele
中科院分区：
文献类型：
--
作者：
Fabiani, Monica;Gordon, Brian A.;Maclin, Edward L.;Pearson, Melanie A.;Brumback-Peltz, Carrie R.;Low, Kathy A.;McAuley, Edward;Sutton, Bradley P.;Kramer, Arthur F.;Gratton, Gabriele
关键词：
脑老化的特征在于血液动力学和神经元反应的变化，这可能受到个体心肺适应性的影响。为了研究神经元和血流动力学变化之间的关系，我们研究了视觉刺激（不同频率的棋盘翻转）引起的大脑活动，在年轻人和老年人不同的身体健康。四个功能性脑测量用于比较从BA17获得的神经元和血液动力学反应：两个反映神经元活动（事件相关光学信号EROS和ERP的C1反应），两个反映功能性血液动力学变化（功能性磁共振成像，fMRI和近红外光谱，NIRS）。结果表明，年轻人和老年人都表现出神经元和血流动力学效应之间的二次关系，在高水平的神经元活动的血流动力学反应的增加减少。虽然老年人表现出减少激活，类似的神经血管耦合功能时，在两个年龄组的功能磁共振成像和脱氧血红蛋白的措施。然而，氧合和脱氧血红蛋白变化之间的耦合随着年龄的增长而减少，随着健身的增加而增加。这些数据表明，偏离线性的神经血管耦合时，可能存在使用血液动力学措施，研究神经元功能。
Brain aging is characterized by changes in both hemodynamic and neuronal responses, which may be influenced by the cardiorespiratory fitness of the individual. To investigate the relationship between neuronal and hemodynamic changes, we studied the brain activity elicited by visual stimulation (checkerboard reversals at different frequencies) in younger adults and in older adults varying in physical fitness. Four functional brain measures were used to compare neuronal and hemodynamic responses obtained from BA17: two reflecting neuronal activity (the event-related optical signal, EROS, and the C1 response of the ERP), and two reflecting functional hemodynamic changes (functional magnetic resonance imaging, fMRI, and near-infrared spectroscopy, NIRS). The results indicated that both younger and older adults exhibited a quadratic relationship between neuronal and hemodynamic effects, with reduced increases of the hemodynamic response at high levels of neuronal activity. Although older adults showed reduced activation, similar neurovascular coupling functions were observed in the two age groups when fMRI and deoxy-hemoglobin measures were used. However, the coupling between oxy-and deoxy-hemoglobin changes decreased with age and increased with increasing fitness. These data indicate that departures from linearity in neurovascular coupling may be present when using hemodynamic measures to study neuronal function.
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影响因子：
3.2
作者：
Buckner, RL;Snyder, AZ;Morris, JC
通讯作者：
Morris, JC
影响因子：
3.2
作者：
Desoto, MC;Fabiani, M;Gratton, G
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Gratton, G
影响因子：
3.7
作者：
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DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
3.3
作者：
Foust, A. J.;Rector, D. M.
通讯作者：
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