The mechanical stress-strain properties of single electrospun collagen type I nanofibers.
The mechanical stress-strain properties of single electrospun collagen type I nanofibers.
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DOI：
10.1016/j.actbio.2010.02.050
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发表时间：
2010-08
影响因子：
9.7
通讯作者：
Guthold M
中科院分区：
文献类型：
--
作者：
Carlisle CR;Coulais C;Guthold M
了解静电纺丝纤维的力学性能对于其在组织工程、材料复合、过滤和药物输送等方面的成功应用具有重要意义。特别是，静电纺丝胶原蛋白由于其生物相容性和促进细胞生长和粘附而具有巨大的生物医学应用潜力。使用联合原子力/光学显微镜技术，我们确定了干燥，静电纺丝胶原蛋白I型的单纤维机械性能。纤维由80 mg/ml胶原蛋白在1，1，1，3，3，3-六氟-2-丙醇中的溶液电纺，并收集在适于通过AFM进行侧向力操纵的条纹表面上。由三点弯曲分析计算的小应变模量为2.82 GPa。随着应变的增加，模量表现出明显的软化。纤维的平均延伸率为初始长度的33%，平均最大应力（断裂应力）为25 MPa。纤维显示出显著的能量损失和超过2%应变的永久变形。
Knowledge of the mechanical properties of electrospun fibers is important for their successful application to tissue engineering, material composites, filtration and drug delivery. In particular, electrospun collagen has great potential for biomedical applications due to its biocompatibility and promotion of cell growth and adhesion. Using a combined atomic force/optical microscopy technique, we determined the single fiber mechanical properties of dry, electrospun collagen type I. The fibers were electrospun from a 80 mg/ml collagen solution in 1,1,1,3,3,3-hexafluro-2-propanol and collected on a striated surface suitable for lateral force manipulation by the AFM. The small strain modulus, calculated from three point bending analysis, was 2.82 GPa. The modulus showed significant softening as strain increased. The average extensibility of the fibers was 33% of their initial length and the average maximum stress (rupture stress) was 25 MPa. The fibers displayed significant energy loss and permanent deformations above 2% strain.
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DOI：
10.1115/1.1385843
发表时间：
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影响因子：
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