Sensitivity-Specificity of Tau and Amyloid β Positron Emission Tomography in Frontotemporal Lobar Degeneration.
Sensitivity-Specificity of Tau and Amyloid β Positron Emission Tomography in Frontotemporal Lobar Degeneration.
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tau和淀粉样β正电子发射断层扫描的敏感性特异性。
DOI：
10.1002/ana.25893
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发表时间：
2020-11
影响因子：
11.2
通讯作者：
Whitwell JL
中科院分区：
文献类型：
--
作者：
Ghirelli A;Tosakulwong N;Weigand SD;Clark HM;Ali F;Botha H;Duffy JR;Utianski RL;Buciuc M;Murray ME;Labuzan SA;Spychalla AJ;Pham NTT;Schwarz CG;Senjem ML;Machulda MM;Baker M;Rademakers R;Filippi M;Jack CR Jr;Lowe VJ;Parisi JE;Dickson DW;Josephs KA;Whitwell JL
研究尸检证实的额颞叶变性 (FTLD) 中 tau 蛋白和β-淀粉样蛋白 (Aβ) 分子 PET 与阿尔茨海默病相关病理学和 4 次重复 tau 病理学之间的关联。 24 名患者接受了 [18F]-Flortaucipir PET 检测，并死于 FTLD（进行性核上性麻痹 (PSP) n=10、皮质基底节变性 (CBD) n=10、FTLD-TDP n=3 和皮克氏病 n=1）。除 1 个外，所有其他均采用匹兹堡化合物 B (PiB) PET。进行 Braak 分期、Aβ 斑块和神经原纤维缠结计数以及半定量 tau 病变评分。在选择匹配 tau 病变分析的时间元感兴趣区域 (ROI)、内嗅皮质和皮质/皮质下区域中计算 Flortaucipir 标准摄取值比率 (SUVR)。计算了全局 PiB SUVR。对一名 PSP 患者进行放射自显影，并使用数字病理学来量化 tau 负荷。 9 例（37.5%）有 Aβ 斑块。总体 PiB SUVR 与 Aβ 斑块计数相关，对于弥漫性斑块具有 100% 特异性和 50% 敏感性。二十一 (87.5%) 患有 Braak I-IV。 Flortaucipir 与内嗅皮质中的神经原纤维缠结计数相关，但在 Braak IV 或原发性年龄相关 tau 病中，内嗅和元 ROI SUVR 并未升高。 Flortaucipir 的摄取模式在 FTLD 病理中有所不同，并且可以区分 PSP 和 CBD。弗洛托西吡与患者红核和中脑被盖区的 tau 损伤评分相关，但与皮质或基底神经节区域的 tau 损伤评分无关。放射自显影显示弗洛托西吡的摄取量极少，尽管弗洛托西吡与各区域的定量 tau 负荷相关。分子 PET 显示出与阿尔茨海默病相关病理的预期相关性，但缺乏检测 FTLD 中轻度阿尔茨海默病病理的敏感性。区域性弗洛托西吡吸收能够将 CBD 和 PSP 分开。
To examine associations between tau and amyloid-beta (Aβ) molecular PET and both Alzheimer-related pathology and 4-repeat tau pathology in autopsy-confirmed frontotemporal lobar degeneration (FTLD). Twenty-four patients had [18F]-Flortaucipir PET and died with FTLD (progressive supranuclear palsy (PSP) n=10, corticobasal degeneration (CBD) n=10, FTLD-TDP n=3 and Pick’s disease n=1). All but one had Pittsburgh Compound-B (PiB) PET. Braak staging, Aβ plaque and neurofibrillary tangle counts and semi-quantitative tau lesion scores were performed. Flortaucipir standard uptake value ratios (SUVRs) were calculated in a temporal meta-region-of-interest (ROI), entorhinal cortex and cortical/subcortical regions selected to match the tau lesion analysis. Global PiB SUVR was calculated. Autoradiography was performed in one PSP patient, with digital pathology used to quantify tau burden. Nine cases (37.5%) had Aβ plaques. Global PiB SUVR correlated with Aβ plaque count, with 100% specificity 50% sensitivity for diffuse plaques. Twenty-one (87.5%) had Braak I-IV. Flortaucipir correlated with neurofibrillary tangle counts in entorhinal cortex, but entorhinal and meta-ROI SUVR were not elevated in Braak IV or primary age-related tauopathy. Flortaucipir uptake patterns differed across FTLD pathologies and could separate PSP and CBD. Flortaucipir correlated with tau lesion score in red nucleus and midbrain tegmentum across patients, but not in cortical or basal ganglia regions. Autoradiography demonstrated minimal uptake of flortaucipir, although flortaucipir correlated with quantitative tau burden across regions. Molecular PET shows expected correlations with Alzheimer-related pathology but lacks sensitivity to detect mild Alzheimer pathology in FTLD. Regional flortaucipir uptake was able to separate CBD and PSP.
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DOI：
10.1136/jnnp-2017-316402
发表时间：
2018-10
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Bevan-Jones WR;Cope TE;Jones PS;Passamonti L;Hong YT;Fryer TD;Arnold R;Allinson KSJ;Coles JP;Aigbirhio FI;Patterson K;O'Brien JT;Rowe JB
通讯作者：
Rowe JB
影响因子：
7.1
作者：
Lowe VJ;Curran G;Fang P;Liesinger AM;Josephs KA;Parisi JE;Kantarci K;Boeve BF;Pandey MK;Bruinsma T;Knopman DS;Jones DT;Petrucelli L;Cook CN;Graff-Radford NR;Dickson DW;Petersen RC;Jack CR Jr;Murray ME
通讯作者：
Murray ME
DOI：
10.1007/s12031-011-9589-0
发表时间：
2011-11
期刊：
Journal of molecular neuroscience : MN
影响因子：
--
作者：
Dickson DW;Kouri N;Murray ME;Josephs KA
通讯作者：
Josephs KA
影响因子：
14
作者：
Lowe, Val J.;Lundt, Emily S.;Murray, Melissa E.
通讯作者：
Murray, Melissa E.
影响因子：
11.2
作者：
Josephs KA;Martin PR;Botha H;Schwarz CG;Duffy JR;Clark HM;Machulda MM;Graff-Radford J;Weigand SD;Senjem ML;Utianski RL;Drubach DA;Boeve BF;Jones DT;Knopman DS;Petersen RC;Jack CR Jr;Lowe VJ;Whitwell JL
通讯作者：
Whitwell JL