Intravascular photoacoustics for image-guidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: a feasibility study.
Intravascular photoacoustics for image-guidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: a feasibility study.
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DOI：
10.7150/thno.7143
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发表时间：
2013
期刊：
影响因子：
12.4
通讯作者：
Emelianov S
中科院分区：
文献类型：
--
作者：
Yeager D;Chen YS;Litovsky S;Emelianov S
最近，组合血管内超声和光声（IVUS/IVPA）成像已被证明是一种新的成像模式，能够可视化动脉粥样硬化斑块的形态（通过IVUS）和细胞/分子组成（通过IVPA），使用内源性组织吸收剂和外源性造影剂。等离子体金纳米颗粒先前被用作IVPA造影剂，其与动脉粥样硬化斑块，特别是吞噬活性巨噬细胞共定位。目前的工作表明，使用IVUS/IVPA成像作为局部温度监测激光加热过程中的工具。评估了在近红外光学波长范围内吸收的二氧化硅涂覆的金纳米棒造影剂的IVPA信号强度的温度依赖性变化，并显示出具有线性关系，斜率大于内源性组织的斜率。随后将连续波激光器并入IVUS/IVPA集成导管中，并用于选择性加热纳米颗粒，同时进行IVPA温度监测。因此，IVUS/IVPA通过等离子体金纳米颗粒造影剂的选择性加热为动脉粥样硬化斑块的检测和温度监测提供了平台。
Recently, combined intravascular ultrasound and photoacoustic (IVUS/IVPA) imaging has been demonstrated as a novel imaging modality capable of visualizing both morphology (via IVUS) and cellular/molecular composition (via IVPA) of atherosclerotic plaques, using both endogenous tissue absorbers and exogenous contrast agents. Plasmonic gold nanoparticles were previously utilized as IVPA contrast agents which co-localize with atherosclerotic plaques, particularly phagocytically active macrophages. The present work demonstrates the use of IVUS/IVPA imaging as a tool for localized temperature monitoring during laser heating. The temperature dependent change in IVPA signal intensity of silica-coated gold nanorod contrast agents absorbing within the near-infrared optical wavelength range is evaluated and shown to have a linear relationship, with a slope greater than that of endogenous tissue. A continuous wave laser was subsequently incorporated into the IVUS/IVPA integrated catheter and utilized to selectively heat the nanoparticles with simultaneous IVPA temperature monitoring. IVUS/IVPA, therefore, provides a platform for detection and temperature monitoring of atherosclerotic plaques through the selective heating of plasmonic gold nanoparticle contrast agents.
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影响因子：
12.4
作者：
Zhang Z;Wang J;Chen C
通讯作者：
Chen C
影响因子：
2.8
作者：
Chen, Yun-Sheng;Frey, Wolfgang;Emelianov, Stanislav
通讯作者：
Emelianov, Stanislav
影响因子：
5.7
作者：
Kolodgie, FD;Virmani, R;Gold, HK
通讯作者：
Gold, HK
影响因子：
7.5
作者：
Obaid, Daniel R.;Calvert, Patrick A.;Bennett, Martin R.
通讯作者：
Bennett, Martin R.
影响因子：
3.8
作者：
Wang B;Su JL;Amirian J;Litovsky SH;Smalling R;Emelianov S
通讯作者：
Emelianov S