Associations of serum carotenoids with visceral adiposity index and lipid accumulation product: a cross-sectional study based on NHANES 2001-2006.
Associations of serum carotenoids with visceral adiposity index and lipid accumulation product: a cross-sectional study based on NHANES 2001-2006.
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DOI：
10.1186/s12944-023-01945-6
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发表时间：
2023-11-30
影响因子：
4.5
通讯作者：
Xiu, Jiancheng
中科院分区：
文献类型：
--
作者：
Yan, Shaohua;Chen, Siyu;Liu, Yumiao;Liang, Hongbin;Zhang, Xinlu;Zhang, Qiuxia;Xiu, Jiancheng
内脏脂肪指数（VAI）和脂质积累积（LAP）是评价内脏脂肪、判断个体代谢健康状况的综合指标。类胡萝卜素是一组天然存在的抗氧化剂，与多种疾病相关。本研究的目的是探讨血清类胡萝卜素浓度与 VAI 或 LAP 之间的关联。数据来自2001年至2006年全国健康与营养调查。采用高效液相色谱法评估血清类胡萝卜素水平。采用多元线性回归模型研究血清类胡萝卜素水平与VAI或LAP之间的关系。使用阈值效应分析和拟合平滑曲线确定潜在的非线性关系。进行分层分析以调查潜在的改变因素。这项基于人群的调查总共纳入了 5,084 名参与者。在多元线性回归中，与血清类胡萝卜素的最低四分位数相比，最高四分位数与 VAI 显着相关，α-胡萝卜素的效应大小 (β) 和 95% CI 为 - 0.98 (- 1.34, - 0.62)，α-胡萝卜素为 - 1.39 (- 1.77, - 1.00) β-胡萝卜素，β-隐黄素为− 0.79 (− 1.18，− 0.41)，叶黄素/玉米黄素为− 0.68 (− 0.96，− 0.39)，反式番茄红素为− 0.88 (− 1.50，− 0.27)。使用分段线性回归模型，发现β胡萝卜素和反式番茄红素与VAI之间存在非线性关系，拐点分别为2.44（log2变换，ug/dL）和3.80（log2变换，ug/dL）。结果表明，α-胡萝卜素、β-隐黄质和叶黄素/玉米黄质与 VAI 呈线性相关。完全调整后，血清类胡萝卜素与 LAP 之间也存在负相关关系。这项研究表明，在美国普通人群中，几种血清类胡萝卜素与 VAI 或 LAP 相关。有必要进行进一步的大型前瞻性调查来支持这一发现。在线版本包含可在 10.1186/s12944-023-01945-6 获取的补充材料。
Visceral adiposity index (VAI) and lipid accumulation product (LAP) are comprehensive indicators to evaluate visceral fat and determine the metabolic health of individuals. Carotenoids are a group of naturally occurring antioxidants associated with several diseases. The purpose of this investigation was to explore the association between serum carotenoid concentration and VAI or LAP. The data were obtained from the National Health and Nutrition Examination Survey between 2001 and 2006. The levels of serum carotenoids were evaluated using high-performance liquid chromatography. Multivariate linear regression models were employed to investigate the relationship between levels of serum carotenoids and VAI or LAP. The potential non-linear relationship was determined using threshold effect analysis and fitted smoothing curves. Stratification analysis was performed to investigate the potential modifying factors. In total, 5,084 participants were included in this population-based investigation. In the multivariate linear regressions, compared to the lowest quartiles of serum carotenoids, the highest quartiles were significantly associated with VAI, and the effect size (β) and 95% CI was − 0.98 (− 1.34, − 0.62) for α-carotene, − 1.39 (− 1.77, − 1.00) for β-carotene, − 0.79 (− 1.18, − 0.41) for β-cryptoxanthin, − 0.68 (− 0.96, − 0.39) for lutein/zeaxanthin, and − 0.88 (− 1.50, − 0.27) for trans-lycopene. Using piece-wise linear regression models, non-linear relationships were found between βcarotene and trans-lycopene and VAI with an inflection point of 2.44 (log2-transformed, ug/dL) and 3.80 (log2-transformed, ug/dL), respectively. The results indicated that α-carotene, β-cryptoxanthin, and lutein/zeaxanthin were linearly associated with VAI. An inverse association was also found between serum carotenoids and LAP after complete adjustments. This study revealed that several serum carotenoids were associated with VAI or LAP among the general American population. Further large prospective investigations are warranted to support this finding. The online version contains supplementary material available at 10.1186/s12944-023-01945-6.
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影响因子：
2.1
作者：
Kahn HS
通讯作者：
Kahn HS
DOI：
10.1016/j.numecd.2017.06.015
发表时间：
2017-10-01
影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
5.9
作者：
Klop B;Elte JW;Cabezas MC
通讯作者：
Cabezas MC