Increased risk of cardiovascular disease in young women following gestational diabetes mellitus.
Increased risk of cardiovascular disease in young women following gestational diabetes mellitus.
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DOI：
10.2337/dc08-0706
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发表时间：
2008-08
期刊：
影响因子：
16.2
通讯作者：
Booth GL
中科院分区：
文献类型：
--
作者：
Shah BR;Retnakaran R;Booth GL
明确妊娠期糖尿病（GDM）妇女妊娠后心血管疾病（CVD）的风险是否增加。研究设计和方法-所有年龄在20-49岁之间的妇女与活产1994年4月至1997年3月在加拿大安大略，被确定。患有GDM的妇女与10名没有GDM的妇女相匹配，并随访CVD。配对队列包括8，191名GDM女性和81，262名非GDM女性。入组时的平均年龄为31岁，中位随访时间为11.5年。CVD事件的风险比为1.71（95% CI 1.08-2.69）。在对随后的2型糖尿病进行校正后，风险比降低（1.13 [95% CI 0.67-1.89]）。结论：与非GDM女性相比，GDM的年轻女性发生CVD的风险显著增加。这种增加的风险大部分归因于随后发生的2型糖尿病。
OBJECTIVE—To determine whether women with gestational diabetes mellitus (GDM) have an increased risk of cardiovascular disease (CVD) following pregnancy. RESEARCH DESIGN AND METHODS—All women aged 20–49 years with live births between April 1994 and March 1997 in Ontario, Canada, were identified. Women with GDM were matched with 10 women without GDM and were followed for CVD. RESULTS—The matched cohorts included 8,191 women with GDM and 81,262 women without GDM. Mean age at entry was 31 years, and median follow-up was 11.5 years. The hazard ratio for CVD events was 1.71 (95% CI 1.08–2.69). After adjustment for subsequent type 2 diabetes, the hazard ratio was attenuated (1.13 [95% CI 0.67–1.89]). CONCLUSIONS—Young women with GDM had a substantially increased risk for CVD compared with women without GDM. Much of this increased risk was attributable to subsequent development of type 2 diabetes.
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