Bone, fat, and muscle interactions in health and disease.
Bone, fat, and muscle interactions in health and disease.
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DOI：
10.20945/2359-3997000000550
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发表时间：
2022-11-11
期刊：
影响因子：
--
通讯作者：
de Paula FJA
中科院分区：
文献类型：
--
作者：
Gomes MM;da Silva MMR;de Araújo IM;de Paula FJA
能量代谢是人体各种器官和组织之间的整合点，不仅在能量底物的消耗方面，而且还因为它集中了由内分泌因子控制的广泛互连网络。因此，组织不仅消耗底物，而且还参与调节能量代谢。特别是软间充质组织在这一过程中起着关键作用。高能量消耗参与骨重塑的认识伴随着证据显示成骨细胞和骨细胞产生影响例如胰岛素敏感性和食欲的因子。此外，肌肉、脂肪和骨组织之间存在显著的相互作用以控制相互组织营养。并非偶然，这些组织的营养和功能变化从个体发育开始直到衰老都是齐头并进的。同样，代谢和营养疾病也会严重影响肌肉骨骼系统和脂肪组织。本叙述性综述强调了间充质组织对骨发育和维持的相互作用的重要性，以及脂肪和肌肉组织功能性和营养性疾病对骨的影响。内分泌代谢弓2022;66（5）：611-20
Energy metabolism is a point of integration among the various organs and tissues of the human body, not only in terms of consumption of energy substrates but also because it concentrates a wide interconnected network controlled by endocrine factors. Thus, not only do tissues consume substrates, but they also participate in modulating energy metabolism. Soft mesenchymal tissues, in particular, play a key role in this process. The recognition that high energy consumption is involved in bone remodeling has been accompanied by evidence showing that osteoblasts and osteocytes produce factors that influence, for example, insulin sensitivity and appetite. Additionally, there are significant interactions between muscle, adipose, and bone tissues to control mutual tissue trophism. Not by chance, trophic and functional changes in these tissues go hand in hand from the beginning of an individual’s development until aging. Likewise, metabolic and nutritional diseases deeply affect the musculoskeletal system and adipose tissue. The present narrative review highlights the importance of the interaction of the mesenchymal tissues for bone development and maintenance and the impact on bone from diseases marked by functional and trophic disorders of adipose and muscle tissues. Arch Endocrinol Metab. 2022;66(5):611-20
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影响因子：
4.1
作者：
Bonewald L
通讯作者：
Bonewald L
DOI：
10.1016/j.bpg.2014.07.008
发表时间：
2014-08-01
影响因子：
3.2
作者：
Dietrich, Peter;Hellerbrand, Claus
通讯作者：
Hellerbrand, Claus
DOI：
10.1056/nejmoa2002449
发表时间：
2020-10-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Carlsson LMS;Sjöholm K;Jacobson P;Andersson-Assarsson JC;Svensson PA;Taube M;Carlsson B;Peltonen M
通讯作者：
Peltonen M
影响因子：
6.2
作者：
Devlin, Maureen J.;Cloutier, Alison M.;Thomas, Nishina A.;Panus, David A.;Lotinun, Sutada;Pinz, Ilka;Baron, Roland;Rosen, Clifford J.;Bouxsein, Mary L.
通讯作者：
Bouxsein, Mary L.
影响因子：
3.7
作者：
de Paula FJ;de Araújo IM;Carvalho AL;Elias J Jr;Salmon CE;Nogueira-Barbosa MH
通讯作者：
Nogueira-Barbosa MH