Why study inner ear hair cell mitochondria?

Why study inner ear hair cell mitochondria?
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DOI:
10.1007/s00106-019-0662-2
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发表时间:
2019-06
期刊:
HNO
影响因子:
0.9
通讯作者:
Lysakowski A
Lysakowski A
中科院分区:
医学4区
文献类型:
--
作者:
Lesus J;Arias K;Kulaga J;Sobkiv S;Patel A;Babu V;Kambalyal A;Patel M;Padron F;Mozaffari P;Jayakumar A;Ghatalah L;Laban N;Bahari R;Perkins G;Lysakowski A

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在其他系统(肌肉、肝脏、神经)中,新的研究检查了线粒体的内部结构,并揭示了关于线粒体是如何构成的以及它们的结构如何影响细胞功能的惊人的新发现。然而,在内耳领域,我们对毛细胞和支持细胞线粒体的结构知识知之甚少,几乎没有关于线粒体亚型或它们在健康和疾病中如何发挥作用的知识。在这篇简短的综述中讨论了对这种知识的需求。
In other systems (muscle, liver, nerves), new studies have examined the internal structure of mitochondria and brought to light striking new findings about how mitochondria are constructed and how their structure affects cell function. In the inner ear field, however, we have little structural knowledge about hair cell and supporting cell mitochondria, and virtually none about mitochondrial subtypes or how they function in health and disease. The need for such knowledge is discussed in this short review.
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