Interaction between the pulmonary stretch receptor and pontine control of expiratory duration.
Interaction between the pulmonary stretch receptor and pontine control of expiratory duration.
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DOI：
10.1016/j.resp.2021.103715
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发表时间：
2021-11
影响因子：
2.3
通讯作者：
Stucke AG
中科院分区：
文献类型：
--
作者：
Zuperku EJ;Hopp FA;Stuth EAE;Stucke AG
臂旁内侧核(MPBN)神经元活动在控制呼气(E)-时程(TE)中起着关键作用。E期肺伸展受体(PSR)活动延长TE。本研究的目的是描述PSR和MPBN对TE的控制之间的相互作用及其潜在机制。对去大脑机械通气犬进行了研究。通过双极微电极电刺激激活MPBN亚区。对切断的中央迷走神经施加低水平电流激活PSR传入。将E期的两种刺激频率模式与膈神经图同步，测量TE。一个控制TE和Prebötzinger/Bötzinger复合体(PreBC/BC)神经元细胞外记录的功能数学模型被用来理解机制。结果表明，MPBN通过衰减对PSR介导的反射进行增益调制。该模型提出了衰减的功能部位，而神经元数据则表明了相关关系。PSR和PB的输入似乎与E递减的神经元相互作用，E递减的神经元从突触上抑制前I期神经元，推迟下一个I期的开始。
Medial parabrachial nucleus (mPBN) neuronal activity plays a key role in controlling expiratory (E)-duration (TE). Pulmonary stretch receptor (PSR) activity during the E-phase prolongs TE. The aims of this study were to characterize the interaction between the PSR and mPBN control of TE and underlying mechanisms. Decerebrated mechanically ventilated dogs were studied. The mPBN subregion was activated by electrical stimulation via bipolar microelectrode. PSR afferents were activated by low-level currents applied to the transected central vagus nerve. Both stimulus-frequency patterns during the E-phase were synchronized to the phrenic neurogram; TE was measured. A functional mathematical model for the control of TE and extracellular recordings from neurons in the preBötzinger/Bötzinger complex (preBC/BC) were used to understand mechanisms. Findings show that the mPBN gain-modulates, via attenuation, the PSR-mediated reflex. The model suggested functional sites for attenuation and neuronal data suggested correlates. The PSR- and PB-inputs appear to interact on E-decrementing neurons, which synaptically inhibit pre-I neurons, delaying the onset of the next I-phase.
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影响因子：
1.9
作者：
BALIS, UJ;MORRIS, KF;LINDSEY, BG
通讯作者：
LINDSEY, BG
影响因子：
2.3
作者：
Romaniuk JR;Dick TE;Bruce EN;DiMarco AF;Kowalski KE
通讯作者：
Kowalski KE
DOI：
10.1016/s0034-5687(00)00205-x
发表时间：
2001-03-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Jordan, D
通讯作者：
Jordan, D
影响因子：
5.5
作者：
Dutschmann, M;Herbert, H
通讯作者：
Herbert, H
影响因子：
3.4
作者：
Dutschmann, Mathias;Herbert, Horst
通讯作者：
Herbert, Horst