Dietary biomarkers: advances, limitations and future directions.
Dietary biomarkers: advances, limitations and future directions.
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DOI：
10.1186/1475-2891-11-109
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发表时间：
2012-12-14
影响因子：
5.4
通讯作者：
Davy BM
中科院分区：
文献类型：
--
作者：
Hedrick VE;Dietrich AM;Estabrooks PA;Savla J;Serrano E;Davy BM
自我报告的饮食摄入量评估方法的主观性对获得准确的饮食摄入量和营养状况提出了许多挑战。这种局限性可以通过使用饮食生物标志物来克服，这些生物标志物能够客观地评估饮食消费（或暴露），而不会出现自我报告的饮食摄入错误的偏差。医学研究所提出了对饮食生物标志物的需求，他们认识到缺乏营养生物标志物是一个需要未来研究的知识缺口。本文的目的是回顾现有的文献，目前可用的饮食生物标志物，包括新的生物标志物的特定食物和膳食成分，并评估的有效性，可靠性和敏感性的标志物。该综述揭示了几种需要额外验证研究的生物标志物;还需要进行研究以产生敏感，特异性，成本效益和非侵入性的饮食生物标志物。新兴的代谢组学领域可能有助于促进食品/营养生物标志物的发展，但食品代谢组学数据库的发展是必要的。估计特定食物和饮食成分摄入量的生物标志物的可用性可以大大加强针对国家建议的遵守情况以及与疾病结果的直接关联的营养研究。有必要进行更多的研究，通过考虑混杂因素来完善现有的生物标志物，建立特定食物摄入量的新指标，并开发具有成本效益的，非侵入性的，快速准确的营养状况测量技术。
The subjective nature of self-reported dietary intake assessment methods presents numerous challenges to obtaining accurate dietary intake and nutritional status. This limitation can be overcome by the use of dietary biomarkers, which are able to objectively assess dietary consumption (or exposure) without the bias of self-reported dietary intake errors. The need for dietary biomarkers was addressed by the Institute of Medicine, who recognized the lack of nutritional biomarkers as a knowledge gap requiring future research. The purpose of this article is to review existing literature on currently available dietary biomarkers, including novel biomarkers of specific foods and dietary components, and assess the validity, reliability and sensitivity of the markers. This review revealed several biomarkers in need of additional validation research; research is also needed to produce sensitive, specific, cost-effective and noninvasive dietary biomarkers. The emerging field of metabolomics may help to advance the development of food/nutrient biomarkers, yet advances in food metabolome databases are needed. The availability of biomarkers that estimate intake of specific foods and dietary components could greatly enhance nutritional research targeting compliance to national recommendations as well as direct associations with disease outcomes. More research is necessary to refine existing biomarkers by accounting for confounding factors, to establish new indicators of specific food intake, and to develop techniques that are cost-effective, noninvasive, rapid and accurate measures of nutritional status.
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DOI：
10.1158/1055-9965.epi-11-0048
发表时间：
2011-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cross AJ;Major JM;Sinha R
通讯作者：
Sinha R
影响因子：
7
作者：
Brennan, Lorraine
通讯作者：
Brennan, Lorraine
影响因子：
2
作者：
Kuhnle, Gunter G. C.;Joosen, Annemiek M. C. P.;Bingham, Sheila A.
通讯作者：
Bingham, Sheila A.
影响因子：
--
作者：
Hardin, Dana S.
通讯作者：
Hardin, Dana S.
影响因子：
4.2
作者：
Andersson, Agneta;Marklund, Matti;Landberg, Rikard
通讯作者：
Landberg, Rikard