Stimulation of formation of adenosine 3',5'-phosphate by histamine in myenteric ganglia isolated from guinea-pig small intestine.
Stimulation of formation of adenosine 3',5'-phosphate by histamine in myenteric ganglia isolated from guinea-pig small intestine.
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组胺刺激从豚鼠小肠分离的肌间神经节中形成腺苷 3,5-磷酸。
DOI：
10.1016/s0014-2999(96)00627-9
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发表时间：
1996
影响因子：
5
通讯作者：
Wood,JD
中科院分区：
文献类型：
--
作者：
Xia,Y;Fertel,RH;Wood,JD
测定了组胺及相关激动剂和拮抗剂对豚鼠小肠肌丛酶解神经节cAMP形成的影响。组胺刺激cAMP的形成具有剂量依赖性和时间依赖性。组胺的刺激作用被组胺h2受体拮抗剂西咪替丁抑制。组胺h11受体拮抗剂、三烯胺或吡咯胺也能抑制组胺的刺激作用，但浓度仅比西咪替丁高3-4个数量级。组胺h2受体激动剂地马普利刺激cAMP的形成呈剂量依赖性。组胺h1受体激动剂2-甲基组胺也能刺激cAMP的产生，但需要的阈值浓度比地马普利高4-5个数量级。我们认为组胺作用于组胺h2受体亚型，刺激豚鼠小肠肌间神经节腺苷酸环化酶和cAMP的形成。
Effects of histamine and related agonists and antagonists on formation of cAMP were determined for enzymatically dissociated ganglia from the myenteric plexus of the guinea-pig small intestine. Formation of cAMP was stimulated by histamine in both dose- and time-dependent manners. The stimulatory action of histamine was suppressed by the histamine H2receptor antagonist, cimetidine. The histamine H1receptor antagonists, tripelennamine or pyrilamine also suppressed the stimulatory action of histamine, but only at concentrations 3–4 orders higher than required for cimetidine. Formation of cAMP was stimulated dose-dependently by the histamine H2receptor agonist, dimaprit. The histamine H1receptor agonist, 2-methyl-histamine, also stimulated cAMP production, but required a threshold concentration 4–5 orders higher than dimaprit. We conclude that histamine acts at the histamine H2receptor subtype to stimulate adenylate cyclase and the formation of cAMP in myenteric ganglia of the guinea-pig small bowel.
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肠道神经免疫相互作用
DOI：
--
发表时间：
1993
期刊：
影响因子：
--
作者：
J. Wood
通讯作者：
J. Wood
肠道神经免疫相互作用中的组胺信号
影响因子：
5.2
作者：
J. Wood
通讯作者：
J. Wood
P 物质是否介导肌间神经丛内的缓慢突触兴奋？
影响因子：
64.8
作者：
Y. Katayama;R. North
通讯作者：
R. North
组胺 H2 受体激动剂在豚鼠远端结肠中协调 Cl- 分泌和收缩。
DOI：
10.1152/ajpgi.1993.265.5.g973
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
Cooke,HJ;Wang,YZ;Rogers,R
通讯作者：
Rogers,R
奥尔巴赫神经丛中血清素介导的缓慢突触兴奋
影响因子：
64.8
作者：
J. Wood;C. Mayer
通讯作者：
C. Mayer