Mid-cervical spinal cord contusion causes robust deficits in respiratory parameters and pattern variability.
Mid-cervical spinal cord contusion causes robust deficits in respiratory parameters and pattern variability.
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DOI：
10.1016/j.expneurol.2018.04.005
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发表时间：
2018-08
影响因子：
5.3
通讯作者：
Alilain WJ
中科院分区：
文献类型：
--
作者：
Warren PM;Campanaro C;Jacono FJ;Alilain WJ
中颈段脊髓挫伤破坏了对吸气肌活动至关重要的通路和运动神经元。本研究旨在确定大鼠挫伤模型在创伤后急性至慢性阶段的“正常”呼吸条件下是否会导致呼吸和呼吸运动功能的可测量缺陷。通过全身体积描记术和肌电图，我们评估了从3天到12周后的颈椎3级（C3）挫伤的呼吸输出。挫伤的动物表现出显着的赤字，在潮气量和分钟的持续从急性到慢性的时间点。我们还通过评估互信息和样本熵研究了挫伤对解释模式变异性的影响程度。中颈挫伤显着和鲁棒性降低的变异性的解释模式。通过多个呼吸肌的肌电图记录进一步证实了挫伤引起的呼吸运动系统的持久缺陷。当通过损伤隔离时，这些挫伤的通路不足以在损伤后的所有时间点维持呼吸活动。总的来说，这些数据表明，与流行的文献相反，可以通过在颈部挫伤后的所有时间点进行多次生理评估来建模和测量深刻且持久的呼吸和呼吸运动缺陷。
Mid-cervical spinal cord contusion disrupts both the pathways and motoneurons vital to the activity of inspiratory muscles. The present study was designed to determine if a rat contusion model could result in a measurable deficit to both ventilatory and respiratory motor function under “normal” breathing conditions at acute to chronic stages post trauma. Through whole body plethysmography and electromyography we assessed respiratory output from three days to twelve weeks after a cervical level 3 (C3) contusion. Contused animals showed significant deficits in both tidal and minute volumes which were sustained from acute to chronic time points. We also examined the degree to which the contusion injury impacted ventilatory pattern variability through assessment of Mutual Information and Sample Entropy. Mid-cervical contusion significantly and robustly decreased the variability of ventilatory patterns. The enduring deficit to the respiratory motor system caused by contusion was further confirmed through electromyography recordings in multiple respiratory muscles. When isolated via a lesion, these contused pathways were insufficient to maintain respiratory activity at all time points post injury. Collectively these data illustrate that, counter to the prevailing literature, a profound and lasting ventilatory and respiratory motor deficit may be modelled and measured through multiple physiological assessments at all time points after cervical contusion injury.
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影响因子：
2.3
作者：
Gill, L. C.;Ross, H. H.;Lee, K. Z.;Gonzalez-Rothi, E. J.;Dougherty, B. J.;Judge, A. R.;Fuller, D. D.
通讯作者：
Fuller, D. D.
影响因子：
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作者：
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Matarazzo, V.
影响因子：
3.3
作者：
Golder, FJ;Reier, PJ;Bolser, DC
通讯作者：
Bolser, DC
影响因子：
2.3
作者：
Chung, Augustine;Fishman, Mikkel;Jacono, Frank J.
通讯作者：
Jacono, Frank J.