Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression.
Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression.
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内源性大麻素系统基因表达反映了前额叶内源性大麻素突触可塑性的性别二态性青少年轨迹在成年期趋于均衡。
DOI：
10.1089/can.2022.0308
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发表时间：
2023
影响因子：
3.8
通讯作者：
Manzoni,OlivierJJ
中科院分区：
文献类型：
--
作者：
Bernabeu,Axel;Bara,Anissa;MurphyGreen,MichelleN;Manduca,Antonia;Wager-Miller,Jim;Borsoi,Milene;Lassalle,Olivier;Pelissier-Alicot,Anne-Laure;Chavis,Pascale;Mackie,Ken;Manzoni,OlivierJJ
性别如何影响青春期前额叶皮层（pfc）突触发育尚不清楚。材料和方法：在这项研究中，我们描述了从青春期到成年期大鼠PFC的性别特异性细胞和突触轨迹。结果：成年女性PFC第5层锥体神经元的兴奋性低于其他发育阶段。内源性大麻素介导的长期抑郁（eCB-LTD）的发育过程与长期增强或mGluR3-LTD不同，是两性二态的。eCB-LTD在雌性青少年中表达，但只在雄性青春期出现。内vanilloid TRPV1R或eCB受体在LTD期间以顺序和两性二态的方式参与。eCB/vanilloid系统的基因表达具有序列性和性别特异性。ltd缺陷的雄性幼崽cb1r相互作用抑制蛋白大麻素受体相互作用蛋白1a和2-花生四烯醇甘油降解酶ABHD6的表达水平升高。ABHD6或MAGL的药理抑制使年轻男性发生LTD，而抑制阿南达胺降解无效。结论：这些结果揭示了大鼠PFC成熟轨迹的性别差异。
Introduction:How sex influences prefrontal cortexes (PFCs) synaptic development through adolescence remains unclear.Materials and Methods:In this study we describe sex-specific cellular and synaptic trajectories in the rat PFC from adolescence to adulthood.Results:The excitability of PFC layer 5 pyramidal neurons was lower in adult females compared with other developmental stages. The developmental course of endocannabinoid-mediated long-term depression (eCB-LTD) was sexually dimorphic, unlike long-term potentiation or mGluR3-LTD. eCB-LTD was expressed in juvenile females but appeared only at puberty in males. Endovanilloid TRPV1R or eCB receptors were engaged during LTD in a sequential and sexually dimorphic manner. Gene expression of the eCB/vanilloid systems was sequential and sex specific. LTD-incompetent juvenile males had elevated expression levels of the CB1R-interacting inhibitory protein cannabinoid receptor interacting protein 1a and of the 2-arachidonoylglycerol-degrading enzyme ABHD6. Pharmacological inhibition of ABHD6 or MAGL enabled LTD in young males, whereas inhibition of anandamide degradation was ineffective.Conclusions:These results reveal sex differences in the maturational trajectories of the rat PFC.
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DOI：
10.1006/bbrc.2000.2406
发表时间：
2000-04-02
影响因子：
3.1
作者：
González, S;Bisogno, T;Fernández-Ruiz, JJ
通讯作者：
Fernández-Ruiz, JJ
影响因子：
1.7
作者：
DEFONSECA, FR;RAMOS, JA;FERNANDEZRUIZ, JJ
通讯作者：
FERNANDEZRUIZ, JJ
影响因子：
1.2
作者：
Wager-Miller, James;Green, Michelle Murphy;Mackie, Ken
通讯作者：
Mackie, Ken
大麻使用和效果的性别差异：大麻使用者的横断面调查。
影响因子：
3.8
作者：
Cuttler C;Mischley LK;Sexton M
通讯作者：
Sexton M
影响因子：
6.1
作者：
Craft, Rebecca M.;Marusich, Julie A.;Wiley, Jenny L.
通讯作者：
Wiley, Jenny L.