Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats.
Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats.
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作者：
Xiong Y;Shen L;Liu KJ;Tso P;Xiong Y;Wang G;Woods SC;Liu M
肥胖和2型糖尿病是全国性和世界性的流行病。由于目前可用的抗肥胖和抗糖尿病药物的疗效和/或安全性问题有限，因此发现新的药物，如这里报道的人参皂苷Rb1(Rb1)，为未来成功的抗肥胖和抗糖尿病疗法的发展提供了令人兴奋的可能性。观察急性腹腔注射Rb1 4周后肥胖大鼠摄食行为的变化，以及Rb1对高脂饮食诱导的肥胖大鼠体重、能量消耗和糖耐量的影响。我们还研究了Rb1对下丘脑信号通路和神经肽的影响。急性腹膜腔注射Rb1可剂量依赖性地抑制食物摄入量，而不会引起毒性迹象。这种对摄食的抑制作用可能是由中枢机制介导的，因为Rb1刺激了参与能量平衡的脑区c-Fos的表达。与此一致，Rb1激活了磷脂酰肌醇3-激酶/Akt信号通路，并抑制了下丘脑NPY基因的表达。在高脂诱导的肥胖大鼠中，四周服用Rb1显著减少食物摄入量、体重增加和体脂含量，并增加能量消耗。Rb1还能显著降低空腹血糖和改善糖耐量，且这些作用强于配对喂养的大鼠，提示虽然Rb1‘S降血糖作用部分归因于减少摄食量和体重，但Rb1可能还有额外的血糖稳态作用。这些结果证实Rb1是一种抗肥胖和降血糖的药物。
Obesity and type 2 diabetes are national and worldwide epidemics. Because currently available antiobesity and antidiabetic drugs have limited efficacy and/or safety concerns, identifying new medicinal agents, such as ginsenoside Rb1 (Rb1) as reported here, offers exciting possibilities for future development of successful antiobesity and antidiabetic therapies. Changes in feeding behavior after acute intraperitoneal administration of Rb1 and the effects of intraperitoneal Rb1 for 4 weeks on body weight, energy expenditure, and glucose tolerance in high-fat diet (HFD)-induced obese rats were assessed. We also examined the effects of Rb1 on signaling pathways and neuropeptides in the hypothalamus. Acute intraperitoneal Rb1 dose-dependently suppressed food intake without eliciting signs of toxicity. This inhibitory effect on feeding may be mediated by central mechanisms because Rb1 stimulated c-Fos expression in brain areas involved in energy homeostasis. Consistent with this, Rb1 activated the phosphatidylinositol 3-kinase/Akt signaling pathway and inhibited NPY gene expression in the hypothalamus. Four-week administration of Rb1 significantly reduced food intake, body weight gain, and body fat content and increased energy expenditure in HFD-induced obese rats. Rb1 also significantly decreased fasting blood glucose and improved glucose tolerance, and these effects were greater than those observed in pair-fed rats, suggesting that although Rb1's antihyperglycemic effect is partially attributable to reduced food intake and body weight; there may be additional effects of Rb1 on glucose homeostasis. These results identify Rb1 as an antiobesity and antihyperglycemic agent.
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影响因子：
2.9
作者：
Liu, M;Maiorano, N;Tso, P
通讯作者：
Tso, P
影响因子：
2.5
作者：
BULLITT, E
通讯作者：
BULLITT, E
影响因子：
4.2
作者：
Mook-Jung, I;Hong, HS;Jung, MW
通讯作者：
Jung, MW
影响因子：
6.7
作者：
Chung, SH;Choi, CG;Park, SH
通讯作者：
Park, SH
影响因子：
3.8
作者：
Hwang, Yong Pil;Jeong, Hye Gwang
通讯作者：
Jeong, Hye Gwang