Local memory CD4 T cell niches in respiratory viral infection.
Local memory CD4 T cell niches in respiratory viral infection.
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DOI：
10.1084/jem.20201733
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发表时间：
2021-08-02
期刊：
影响因子：
--
通讯作者：
Pepper M
中科院分区：
文献类型：
--
作者：
Pruner KB;Pepper M
Pruner and Pepper provide a timely literature review detailing the critical, heterogenous functions of lung resident CD4 memory T cells during respiratory viral infection. Implications for vaccine design and protection from heterologous influenza and SARS-CoV-2 reinfection are discussed. Respiratory viral infections present a major threat to global health and prosperity. Over the past century, several have developed into crippling pandemics, including the SARS-CoV-2 virus. Although the generation of neutralizing serum antibodies in response to natural immunity and vaccination are considered to be hallmarks of viral immune protection, antibodies from long-lived plasma cells are subject to immune escape from heterologous clades of zoonotic, recombined, or mutated viruses. Local immunity in the lung can be generated through resident memory immune subsets that rapidly respond to secondary infection and protect from heterologous infection. Although many immune cells are required to achieve the phenomenon of resident memory, herein we highlight the pleiotropic functions of CD4 tissue resident memory T cells in the lung and discuss the implications of resident memory for vaccine design.
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DOI：
10.4049/jimmunol.1000423
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fulton RB;Meyerholz DK;Varga SM
通讯作者：
Varga SM
影响因子：
30.5
作者：
Dogan, Ismail;Bertocci, Barbara;Weill, Jean-Claude
通讯作者：
Weill, Jean-Claude
影响因子：
5.4
作者：
Cormier, Stephania A.;Shrestha, Bishwas;You, Dahui
通讯作者：
You, Dahui
影响因子：
16.6
作者：
Vu Van D;Beier KC;Pietzke LJ;Al Baz MS;Feist RK;Gurka S;Hamelmann E;Kroczek RA;Hutloff A
通讯作者：
Hutloff A
流感感染后气道中依赖于整合素 VLA-1 的独特组织记忆 CD4+ T 细胞群的鉴定。
DOI：
10.4049/jimmunol.0902281
发表时间：
2010-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chapman TJ;Topham DJ
通讯作者：
Topham DJ