Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1.
Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1.
复制标题
流感感染后气道中依赖于整合素 VLA-1 的独特组织记忆 CD4+ T 细胞群的鉴定。
DOI：
10.4049/jimmunol.0902281
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发表时间：
2010-04-01
期刊：
影响因子：
--
通讯作者：
Topham DJ
中科院分区：
文献类型：
--
作者：
Chapman TJ;Topham DJ
在对流感感染的免疫应答过程中，活化的T细胞分布到淋巴和淋巴外组织，包括感染的气道，在那里直接识别携带病毒抗原的细胞。胶原结合α1β1整联蛋白VLA-1对于气道中记忆性CD 8 + T细胞的发育是必需的，但尽管由一些CD 4 + T细胞表达，但其意义尚未得到证实。我们研究了VLA-1在小鼠原发性或继发性流感感染期间和之后对病毒特异性CD 4 + T细胞的作用。在初次感染期间采集的所有组织中，表达CD 49 a（α1整联蛋白）的CD 4+细胞比例较低，但在病毒清除后气道中增加。此外，在二次流感攻击的前24小时期间，来自气道的大多数分泌IFN-γ的效应CD 4 + T细胞在CD 49 a+群体中。与CD 49 a −细胞相比，气道CD 49 a + CD 4+细胞表达的凋亡标志物也减少，并且从α1−/−小鼠的气道中回收的记忆或效应CD 4+细胞较少，但淋巴组织似乎未受影响。这些数据表明，VLA-1表达定义了一群组织记忆CD 4 + T细胞，这些细胞在再次感染时充当快速效应器，并且VLA-1表达是其在气道中积累的组成部分。
During the immune response to influenza infection, activated T cells are distributed to both lymphoid and extralymphoid tissues, including the infected airways where direct recognition of viral antigen-bearing cells takes place. The collagen binding α1β1 integrin VLA-1 is essential for the development of memory CD8+ T cells in the airways but while expressed by some CD4+ T cells, its significance has not been demonstrated. We investigated the role of VLA-1 on virus-specific CD4+ T cells during and after primary or secondary influenza infection of mice. The proportion of CD4+ cells expressing CD49a (α1 integrin) was low in all tissues sampled during primary infection, but increased in the airways after viral clearance. Furthermore, during the first 24hr of a secondary influenza challenge, the majority of IFN-γ secreting effector CD4+ T cells from the airways were in the CD49a+ population. Airway CD49a+ CD4+ cells also expressed reduced markers of apoptosis compared to CD49a− cells, and fewer memory or effector CD4+ cells could be recovered from airways of α1−/− mice, though lymphoid tissues appeared unaffected. These data suggest VLA-1 expression defines a population of tissue-memory CD4+ T cells that act as rapid effectors upon re-infection, and VLA-1 expression is integral to their accumulation in the airways.
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