Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study.
Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study.
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循环ANGPTL8水平和肾功能下降的风险：来自4C研究的结果
DOI：
10.1186/s12933-021-01317-3
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发表时间：
2021-06-24
影响因子：
9.3
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Zou H;Xu Y;Meng X;Li D;Chen X;Du T;Yang Y;Chen Y;Shao S;Yuan G;Zhou X;Hu S;He W;Ma D;Xie J;Zhang B;Zhang J;Li W;Liu Z;Yu X
ANGPTL8是一种重要的脂质代谢调节因子，最近被证明具有额外的细胞内和受体介导的功能。本研究旨在通过一项队列研究调查血液中ANGPTL8水平及其与肾功能下降风险的潜在关联。我们分析了2311名来自中国心脏代谢疾病和癌症队列（4C）研究的40岁及以上的参与者。肾功能下降定义为肾小球滤过率（eGFR）低于每1.73 m2体表面积每分钟60 mL， eGFR较基线下降≥30%，慢性肾病（CKD）相关住院或死亡，或终末期肾病。使用多变量校正Cox比例风险模型评估基线ANGPTL8水平与肾功能下降之间的关系，并使用治疗权重逆可能性（IPTW）来防止过拟合。在中位3.8年的随访期间，有136例（5.9%）肾功能下降。我们发现，在随访期间，肾功能下降个体的血清ANGPTL8水平在基线时高于无肾功能下降个体（718.42±378.17比522.04±283.07 pg/mL, p < 0.001）。与第一个四分位数相比，第四个ANGPTL8四分位数的肾功能下降的多变量校正风险比（95%置信区间[CI]）为2.59 （95% CI, 1.41-4.77）。此外，与第一个ANGPTL8四分位数的患者相比，第四个ANGPTL8四分位数的患者更有可能报告更高阶段的CKD（相对风险：1.33;95% CI, 1.01-1.74）。在IPTW模型中，回归分析的结论没有改变。多变量调整限制三次样条分析表明，ANGPTL8与肾功能下降呈线性关系（非线性趋势p = 0.66，线性趋势p < 0.001）。循环ANGPTL8水平较高的参与者肾功能下降的风险增加，强调了未来研究解决ANGPTL8在CKD中的病理生理作用的重要性。在线版本包含补充材料，可在10.1186/s12933-021-01317-3获得。
ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed to investigate circulating levels of ANGPTL8 and its potential association with the risk of kidney function decline in a cohort study. We analysed 2,311 participants aged 40 years old and older from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. Kidney function decline was defined as an estimated glomerular filtration rate (eGFR) less than 60 mL per minute per 1.73 m2 of body surface area, a decrease in eGFR of ≥ 30% from baseline, chronic kidney disease (CKD)-related hospitalization or death, or end-stage renal disease. The association between baseline ANGPTL8 levels and kidney function decline was assessed using multivariable-adjusted Cox proportional hazards models, and inverse possibility of treatment weight (IPTW) was utilized to prevent overfitting. There were 136 (5.9%) cases of kidney function decline over a median of 3.8 years of follow-up. We found that serum ANGPTL8 levels at baseline were elevated in individuals with kidney function decline compared to those without kidney function decline during follow-up (718.42 ± 378.17 vs. 522.04 ± 283.07 pg/mL, p < 0.001). Compared with the first quartile, multivariable-adjusted hazard ratio (95% confidence intervals [CIs]) for kidney function decline was 2.59 (95% CI, 1.41–4.77) for the fourth ANGPTL8 quartile. Furthermore, compared with patients in the first ANGPTL8 quartile, those in the fourth ANGPTL8 quartile were more likely to report a higher stage of CKD (relative risk: 1.33; 95% CI, 1.01–1.74). The conclusions of the regression analyses were not altered in the IPTW models. Multivariable-adjusted restricted cubic spline analyses suggested a linear relationship of ANGPTL8 with kidney function decline (p for nonlinear trend = 0.66, p for linear trend < 0.001). Participants with higher circulating ANGPTL8 levels were at increased risk for kidney function decline, highlighting the importance of future studies addressing the pathophysiological role of ANGPTL8 in CKD. The online version contains supplementary material available at 10.1186/s12933-021-01317-3.
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影响因子：
9.3
作者：
Chen CC;Susanto H;Chuang WH;Liu TY;Wang CH
通讯作者：
Wang CH
胰岛素通过 PI3K/Akt 途径上调 betatropin 表达
影响因子：
4.6
作者：
Lu P;Chen X;Zhang Z;Zhang J;Yang Y;Liu Z;Xie J;Shao S;Zhou X;Hu S;He W;Zhao J;Yu X
通讯作者：
Yu X
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
4.5
作者：
Abu-Farha M;Cherian P;Qaddoumi MG;AlKhairi I;Sriraman D;Alanbaei M;Abubaker J
通讯作者：
Abubaker J