Carotid Artery Stiffness: Imaging Techniques and Impact on Cerebrovascular Disease.
Carotid Artery Stiffness: Imaging Techniques and Impact on Cerebrovascular Disease.
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DOI：
10.3389/fcvm.2022.852173
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发表时间：
2022
影响因子：
3.6
通讯作者：
Gupta A
中科院分区：
文献类型：
--
作者：
Baradaran H;Gupta A
动脉僵硬度是血管老化和动脉粥样硬化的重要指标。尽管许多著名的流行病学队列研究都对其进行了测量，但由于测量困难、定义变化以及治疗的不确定性等多种原因，动脉僵硬度在常规临床实践中经常被忽视。中央动脉僵硬度是主动脉僵硬度的替代指标，是最常测量的动脉僵硬度标志。除了中央硬度之外，还有许多基于超声的技术来测量局部血管硬度，包括颈动脉硬度。有证据表明，局部颈动脉僵硬度和中央动脉僵硬度测量值均与多种脑血管过程相关，包括中风和认知功能障碍。支持这种关联的机制解释包括脑微血管系统经历的血流负荷增加导致脑实质损伤。在本文中，我们回顾了颈动脉僵硬度测量的定义以及支撑其与斑块发展和下游脑病理学相关的病理生理机制。我们将回顾有关颈动脉僵硬度测量与下游表现之间关系的证据，包括中风、脑部 MR 检测到的脑小血管疾病（如白质高信号和隐性脑梗塞、脑萎缩和认知功能障碍）。凭借一致的定义、测量方法和进一步的科学支持，颈动脉僵硬可能有潜力成为中风和认知能力下降的基于成像的危险因素。
Arterial stiffness is an important measure of vascular aging and atherosclerosis. Though it is measured in many well-known epidemiologic cohort studies, arterial stiffness is often overlooked in routine clinical practice for a number of reasons including difficulties in measurement, variations in definition, and uncertainties surrounding treatment. Central arterial stiffness, a surrogate for aortic stiffness, is the most commonly measured marker of arterial stiffness. In addition to central stiffness, there are also a number of ultrasound based techniques to measure local vascular stiffness, including carotid stiffness. There is evidence that both local carotid stiffness and central arterial stiffness measures are associated with multiple cerebrovascular processes, including stroke and cognitive dysfunction. Mechanistic explanations supporting this association include increased flow load experienced by the cerebral microvasculature leading to cerebral parenchymal damage. In this article, we review definitions of carotid artery stiffness measures and pathophysiologic mechanisms underpinning its association with plaque development and downstream cerebral pathology. We will review the evidence surrounding the association of carotid stiffness measures with downstream manifestations including stroke, cerebral small vessel disease detected on brain MR such as white matter hyperintensities and covert brain infarctions, brain atrophy, and cognitive dysfunction. With consistent definitions, measurement methods, and further scientific support, carotid stiffness may have potential as an imaging-based risk factor for stroke and cognitive decline.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
4.8
作者：
Gupta A;Iadecola C
通讯作者：
Iadecola C
影响因子：
5.3
作者：
Geijselaers, Stefan L. C.;Sep, Simone J. S.;Stehouwer, Coen D. A.
通讯作者：
Stehouwer, Coen D. A.
影响因子：
3.3
作者：
DuBose, Lyndsey E.;Voss, Michelle W.;Pierce, Gary L.
通讯作者：
Pierce, Gary L.
影响因子：
4.2
作者：
Chao, L. L.;Mueller, S. G.;Weiner, M. W.
通讯作者：
Weiner, M. W.