Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.
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DOI：
10.1007/s00018-014-1666-4
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发表时间：
2014-10
影响因子：
8
通讯作者：
Berman, Zachary
中科院分区：
文献类型：
--
作者：
Yan, Shan;Sorrell, Melanie;Berman, Zachary
关键词：
为了维持基因组的稳定性，细胞已经进化出各种DNA修复途径来处理氧化性DNA损伤。DNA损伤反应（DDR）途径，包括ATM-Chk 2和ATR-Chk 1检查点，也在氧化应激中被激活，以协调DNA修复、细胞周期进程、转录、凋亡和衰老。一些研究表明，DDR途径可以调节DNA修复途径。另一方面，越来越多的证据表明，DNA修复途径也可以调节DDR途径的激活。在这篇综述中，我们总结了我们目前的理解，如何各种DNA修复和DDR途径被激活，主要是从真核生物的研究氧化DNA损伤。特别是，我们分析了氧化应激中DNA修复和DDR途径之间的功能相互作用。更好地理解细胞对氧化应激的反应可能为治疗人类疾病，如癌症和神经退行性疾病提供新的途径。
To maintain genome stability, cells have evolved various DNA repair pathways to deal with oxidative DNA damage. DNA damage response (DDR) pathways, including ATM-Chk2 and ATR-Chk1 checkpoints, are also activated in oxidative stress to coordinate DNA repair, cell cycle progression, transcription, apoptosis, and senescence. Several studies demonstrate that DDR pathways can regulate DNA repair pathways. On the other hand, accumulating evidence suggests that DNA repair pathways may modulate DDR pathway activation as well. In this review, we summarize our current understanding of how various DNA repair and DDR pathways are activated in response to oxidative DNA damage primarily from studies in eukaryotes. In particular, we analyze the functional interplay between DNA repair and DDR pathways in oxidative stress. A better understanding of cellular response to oxidative stress may provide novel avenues of treating human diseases, such as cancer and neurodegenerative disorders.
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