Cytokines and angiogenesis in the corpus luteum.

Cytokines and angiogenesis in the corpus luteum.
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DOI:
10.1155/2013/420186
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发表时间:
2013
影响因子:
4.6
通讯作者:
Skarzynski DJ
Skarzynski DJ
中科院分区:
医学3区
文献类型:
--
作者:
Galvão AM;Ferreira-Dias G;Skarzynski DJ

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在成人中,生理性血管生成是一种罕见的事件,除了少数例外,因为女性生殖器官的组织生长和功能所需的血管生成。特别是在黄体(CL)中,血管生成过程的调节似乎受到促血管生成因子和抗血管生成因子之间平衡产生的相反作用的严格控制。正是极其快速的事件序列决定了血管和非血管结构的巨大变化,使 CL 成为血管生成研究的绝佳模型。使用母马 CL 作为模型,有关局部产生的细胞因子的报告,如肿瘤坏死因子 α (TNF)、干扰素 γ (IFNG) 或 Fas 配体 (FASL),指出了它们在整个黄体期血管生成活性调节中的作用。因此,本综述的主要目的是强调免疫细胞、内皮细胞和黄体类固醇生成细胞之间的相互作用,涉及马 CL 建立和消退过程中的血管动力学/变化。
In adults, physiological angiogenesis is a rare event, with few exceptions as the vasculogenesis needed for tissue growth and function in female reproductive organs. Particularly in the corpus luteum (CL), regulation of angiogenic process seems to be tightly controlled by opposite actions resultant from the balance between pro- and antiangiogenic factors. It is the extremely rapid sequence of events that determines the dramatic changes on vascular and nonvascular structures, qualifying the CL as a great model for angiogenesis studies. Using the mare CL as a model, reports on locally produced cytokines, such as tumor necrosis factor α (TNF), interferon gamma (IFNG), or Fas ligand (FASL), pointed out their role on angiogenic activity modulation throughout the luteal phase. Thus, the main purpose of this review is to highlight the interaction between immune, endothelial, and luteal steroidogenic cells, regarding vascular dynamics/changes during establishment and regression of the equine CL.
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