Non-natural nucleic acids for synthetic biology.
Non-natural nucleic acids for synthetic biology.
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DOI:
10.1016/j.cbpa.2009.09.030
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发表时间:
2009-12
影响因子:
7.8
通讯作者:
Appella, Daniel H.
中科院分区:
文献类型:
--
作者:
Appella, Daniel H.
Genetic manipulation is an important facet of synthetic biology but can be complicated by undesired nuclease degradation. Incorporating non-natural nucleic acids into a gene could convey resistance to nucleases and promote expression. The compatibility of non-natural nucleosides with polymerases is reviewed with a focus on results from the past two years. Details are provided about how the different systems could be useful in synthetic biology.
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