Increased viscosity of milk during infant feeding improves swallow safety through modifying sucking in an animal model.
Increased viscosity of milk during infant feeding improves swallow safety through modifying sucking in an animal model.
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DOI：
10.1111/jtxs.12599
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发表时间：
2021-12
影响因子：
3.2
通讯作者：
German, Rebecca Z.
中科院分区：
文献类型：
--
作者：
Mayerl, Christopher J.;Edmonds, Chloe E.;Gould, Francois D. H.;German, Rebecca Z.
对于频繁误吸、乳汁进入气道的婴儿，通常会开出浓稠液体以提高吞咽安全性。然而，关于浓缩牛奶对婴儿喂养效果的研究仅限于记录误吸率和浓缩后牛奶的流变特性。因此，我们对喂养高粘度牛奶期间导致性能差异的生理和行为机制知之甚少。了解在不同粘度下驱动性能变化的生理和行为机制尤其重要，因为参与喂养的结构对感官刺激的反应不同。我们使用小猪（一种经过验证的婴儿喂养动物模型）来测试舌头、软腭和舌骨对吸吮和吞咽过程中粘度变化的反应，以及测量吞咽安全性和食团大小。我们发现，在吸吮和吞咽过程中，舌头的运动表现出与粘稠液体相关的实质性变化，但吞咽过程中的咽部传输时间以及舌骨和软腭运动不受影响。这项工作证明了婴儿喂养的综合性质，以及与吸吮相关的行为对与牛奶粘度变化相关的感觉运动反馈比与咽部吞咽相关的行为更敏感，这可能是由于其反射性质。
Infants experiencing frequent aspiration, the entry of milk into the airway, are often prescribed thickened fluids to improve swallow safety. However, research on the outcomes of thickened milk on infant feeding have been limited to documenting rates of aspiration and the rheologic properties of milk following thickening. As a result, we have little insight into the physiologic and behavioral mechanisms driving differences in performance during feeding on high viscosity milk. Understanding the physiologic and behavioral mechanisms driving variation in performance at different viscosities is especially critical, because the structures involved in feeding respond differently to sensory stimulation. We used infant pigs, a validated animal model for infant feeding, to test how the tongue, soft palate, and hyoid respond to changes in viscosity during sucking and swallowing, in addition to measuring swallow safety and bolus size. We found that the tongue exhibited substantive changes in its movements associated with thickened fluids during sucking and swallowing, but that pharyngeal transit time as well as hyoid and soft palate movements during swallowing were unaffected. This work demonstrates the integrated nature of infant feeding and that behaviors associated with sucking are more sensitive to sensorimotor feedback associated with changes in milk viscosity than those associated with the pharyngeal swallow, likely due to its reflexive nature.
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影响因子：
2.5
作者：
Hori, Kazuhiro;Taniguchi, Hiroshige;Hayashi, Hirokazu;Magara, Jin;Minagi, Yoshitomo;Li, Qiang;Ono, Takahiro;Inoue, Makoto
通讯作者：
Inoue, Makoto
影响因子：
2.6
作者：
Ding, Peng;Campbell-Malone, Regina;Holman, Shaina D.;Lukasik, Stacey L.;Fukuhara, Takako;Gierbolini-Norat, Estela M.;Thexton, Allan J.;German, Rebecca Z.
通讯作者：
German, Rebecca Z.
影响因子：
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作者：
Hayoun, P.;Engmann, J.;Ramaioli, M.
通讯作者：
Ramaioli, M.
影响因子：
2.6
作者：
Ballester A;Gould F;Bond L;Stricklen B;Ohlemacher J;Gross A;DeLozier K;Buddington R;Buddington K;Danos N;German R
通讯作者：
German R
影响因子：
2.6
作者：
Gould FDH;Yglesias B;Ohlemacher J;German RZ
通讯作者：
German RZ