Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana.
Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana.
复制标题
拟南芥的主要健身折衷的自然等位基因变异。
作者：
植物可以抵御各种各样的敌人，但最引人注目的观察之一是这种防御的有效性，无论是在物种内部还是物种之间。其中一些变化可以解释为来自不同攻击模式的病原体的相互冲突的压力。第二种解释来自进化的拔河，病原体适应以逃避检测，直到植物进化出新的识别病原体入侵的能力。然而，如果选择足够强，易感宿主应该保持罕见。事实并非如此，最好的理由是在无虫害的环境中进行结构性防御所产生的费用。使用正向遗传学和全基因组关联分析相结合，我们证明了在一个单一的基因座，加速细胞死亡6（ACD 6），等位基因多样性的基础上显着多效性差异，营养生长和抗微生物感染和草食性之间的天然拟南芥菌株。与参考等位基因相比，过度活跃的ACD 6等位基因强烈增强了对来自不同门的广泛病原体的抗性，但同时减缓了新叶的产生并大大降低了成熟叶的生物量。该等位基因在全世界范围的A. thaliana和当地人群内，与此等位基因提供了大量的健身效益，尽管其对增长的巨大影响一致。
Plants can defend themselves against a wide array of enemies, yet one of the most striking observations is the variability in the effectiveness of such defences, both within and between species. Some of this variation can be explained by conflicting pressures from pathogens with different modes of attack. A second explanation comes from an evolutionary tug of war, in which pathogens adapt to evade detection, until the plant has evolved new recognition capabilities for pathogen invasion. If selection is, however, sufficiently strong, susceptible hosts should remain rare. That this is not the case is best justified by costs incurred from constitutive defences in a pest free environment. Using a combination of forward genetics and genome-wide association analyses, we demonstrate that allelic diversity at a single locus, ACCELERATED CELL DEATH 6 (ACD6), underpins dramatic pleiotropic differences in both vegetative growth and resistance to microbial infection and herbivory among natural Arabidopsis thaliana strains. A hyperactive ACD6 allele, compared to the reference allele, strongly enhances resistance to a broad range of pathogens from different phyla, but at the same time slows the production of new leaves and greatly reduces the biomass of mature leaves. This allele segregates at intermediate frequency both throughout the worldwide range of A. thaliana and within local populations, consistent with this allele providing substantial fitness benefits despite its drastic impact on growth.
登录
查看更多内容
影响因子：
56.9
作者：
Alonso, JM;Stepanova, AN;Ecker, JR
通讯作者：
Ecker, JR
影响因子：
7.2
作者：
Adam, L;Somerville, SC
通讯作者：
Somerville, SC
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
4.5
作者：
Bomblies K;Yant L;Laitinen RA;Kim ST;Hollister JD;Warthmann N;Fitz J;Weigel D
通讯作者：
Weigel D
影响因子：
5.1
作者：
Hellens, RP;Edwards, EA;Mullineaux, PM
通讯作者：
Mullineaux, PM