The relationship between mismatch response and the acoustic change complex in normal hearing infants.
The relationship between mismatch response and the acoustic change complex in normal hearing infants.
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DOI：
10.1016/j.clinph.2018.02.132
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Gilley PM
中科院分区：
文献类型：
--
作者：
Uhler KM;Hunter SK;Tierney E;Gilley PM
研究失配反应 (MMR) 和声学变化复合体 (ACC) 在评估婴儿言语歧视方面的效用。记录了 48 名 1.77 至 4.57 个月听力正常的婴儿（24 名男性，20 名女性）在睡眠期间对两项听觉辨别任务的反应的连续脑电图。 ACC 是根据三元音序列 (/i/-/a/-/i/) 记录的。 MMR 是根据标准元音 /a/（概率 85%）和异常元音 /i/（概率 15%）记录的。先验比较包括：年龄、性别和睡眠状态。这些是针对比较的三个带通滤波器设置（1-18、1-30 和 1-40 Hz）中的每一个单独进行的。先验测试显示，对于三种过滤器设置中的任何一种，年龄、性别或睡眠状态的 MMR 或 ACC 没有差异。在所有 44 名睡眠婴儿中均显着观察到 ACC 和 MMR 反应（排除了 4 名婴儿的数据）。 ACC 观察到的显着差异在于刺激的开始和消失。然而，ACC 中言语刺激的变化并未观察到群体或个体差异。 MMR 显示在刺激开始和刺激抵消时出现两个突出的峰值。排列 t 检验显示标准刺激和异常刺激之间的起始和偏移 MMR 峰值存在显着差异 (p<0.01)。 1-18 Hz 滤波器设置揭示了 MMR 范式中所有参与者的显着差异。观察到 ACC 和 MMR 对听觉刺激的反应，表明婴儿即使在睡眠期间也能感知和处理语音信息。在 MMR 范式中观察到标准反应和异常反应之间存在显着差异，但在 ACC 范式中未观察到。这些发现表明 MMR 对检测听觉/言语辨别处理很敏感。本文指出 MMR 可用于识别正常听力婴儿的歧视。这表明 MMR 有潜力用于听力损失婴儿来验证助听器验配。
To examine the utility of the mismatch response (MMR) and acoustic change complex (ACC) for assessing speech discrimination in infants. Continuous EEG was recorded during sleep from 48 (24 male, 20 female) normally hearing infants aged 1.77 to 4.57 months in response to two auditory discrimination tasks. ACC was recorded in response to a three-vowel sequence (/i/-/a/-/i/). MMR was recorded in response to a standard vowel, /a/, (probability 85%), and to a deviant vowel, /i/, (probability of 15%). A priori comparisons included: age, sex, and sleep state. These were conducted separately for each of the three bandpass filter settings were compared (1-18, 1-30, and 1-40 Hz). A priori tests revealed no differences in MMR or ACC for age, sex, or sleep state for any of the three filter settings. ACC and MMR responses were prominently observed in all 44 sleeping infants (data from four infants were excluded). Significant differences observed for ACC were to the onset and offset of stimuli. However, neither group nor individual differences were observed to changes in speech stimuli in the ACC. MMR revealed two prominent peaks occurring at the stimulus onset and at the stimulus offset. Permutation t-tests revealed significant differences between the standard and deviant stimuli for both the onset and offset MMR peaks (p<0.01). The 1-18 Hz filter setting revealed significant differences for all participants in the MMR paradigm. Both ACC and MMR responses were observed to auditory stimulation suggesting that infants perceive and process speech information even during sleep. Significant differences between the standard and deviant responses were observed in the MMR, but not ACC paradigm. These findings suggest that the MMR is sensitive to detecting auditory/speech discrimination processing. This paper identified that MMR can be used to identify discrimination in normal hearing infants. This suggests that MMR has potential for use in infants with hearing loss to validate hearing aid fittings.
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影响因子：
3.7
作者：
Bishop DV;Hardiman MJ
通讯作者：
Hardiman MJ
影响因子：
4.7
作者：
Ceponiene, R;Rinne, T;Näätänen, R
通讯作者：
Näätänen, R
影响因子：
4.3
作者：
Grigg-Damberger, Madeleine M.
通讯作者：
Grigg-Damberger, Madeleine M.
影响因子：
4.7
作者：
Gilley, Phillip M.;Sharma, Mridula;Purdy, Suzanne C.
通讯作者：
Purdy, Suzanne C.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y