Recovery of skin barrier properties after sonication in human subjects.
Recovery of skin barrier properties after sonication in human subjects.
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DOI：
10.1016/j.ultrasmedbio.2009.04.001
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发表时间：
2009-08
影响因子：
2.9
通讯作者：
Prausnitz, Mark R.
中科院分区：
文献类型：
--
作者：
Gupta, Jyoti;Prausnitz, Mark R.
SonoPrep®超声波皮肤渗透系统在临床上用于增加皮肤渗透性，实现快速、非侵入性的局部麻醉剂输送。这项研究验证了这样一个假设，即超声可以为持续的经皮给药和诊断性代谢物提取产生长期的皮肤渗透性增加。为了达到这一目的，对10名健康成年受试者的前臂掌侧皮肤进行了超声波探伤。作为皮肤通透性的替代测量，在48小时内，在封闭和非封闭部位每小时测量一次皮肤阻抗。超声波显著增加皮肤通透性，表现为皮肤阻抗的大幅下降。在闭塞状态下，超声处理的皮肤在整个闭塞的42小时内保持高渗透性，随后在去除闭塞后渗透性立即下降。在没有阻塞的情况下，超声皮肤在整个48小时的实验中保持了较高的通透性，但恢复屏障功能的速度更快。因此，超声可以在很长一段时间内增加皮肤的通透性，特别是在闭塞的情况下，并有可能促进持续的经皮给药和诊断性代谢物的提取。
The SonoPrep® ultrasonic skin permeation system is used clinically to increase skin permeability for rapid, non-invasive delivery of local anaesthetics. This study tested the hypothesis that sonication can generate a long-lived increase of skin permeability for continuous transdermal drug delivery and diagnostic metabolite extraction. In order to accomplish this, the volar forearm skin of ten healthy adult subjects was sonicated. As a surrogate measure of skin permeability, skin electrical impedance was measured at occluded and non-occluded sites every hour over a period of 48 h. Sonication dramatically increased skin permeability, as demonstrated by a large drop in skin impedance. Under occlusion, sonicated skin remained highly permeable during the entire 42 h period of occlusion, which was followed by an immediate decrease in permeability upon removal of occlusion. Without occlusion, sonicated skin retained elevated permeability throughout the 48 h experiment, but regained its barrier function more quickly. Therefore, sonication can increase skin permeability for prolonged periods of time, especially under the effect of occlusion, and has potential to facilitate continuous transdermal drug delivery and diagnostic metabolite extraction.
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