Expression of trichohyalin in dermatological disorders: a comparative study with involucrin and filaggrin by immunohistochemical staining.
Expression of trichohyalin in dermatological disorders: a comparative study with involucrin and filaggrin by immunohistochemical staining.
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皮肤病中毛透明蛋白的表达：通过免疫组织化学染色与外皮蛋白和聚丝蛋白进行比较研究。
DOI：
10.1080/000155599750011336
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发表时间：
1999
影响因子：
3.6
通讯作者：
Y. P. Kim
中科院分区：
文献类型：
--
作者：
S. Lee;J. B. Lee;J. J. Seo;Y. P. Kim
为了研究透明质酸在皮肤终末分化过程中的作用，对透明质酸及其相关蛋白、丝聚蛋白和外皮蛋白进行了免疫组织化学研究。在与肿瘤无关的皮肤疾病中，在银屑病、鱼鳞病、毛发角化病、汗孔角化病、慢性皮炎和愈伤组织的一些颗粒细胞或角质层中发现了弱的透明质蛋白表达。类似的透明质酸表达在表皮肿瘤中被发现，如脂溢性角化病、光化性角化病、Bowen病和分化良好的鳞状细胞癌。在滤泡性肿瘤中，透明质酸在上皮瘤、角化性基底细胞上皮瘤、增殖性毛鞘瘤、毛鞘瘤、毛母质瘤和角化棘皮瘤中表达阳性。从与丝聚蛋白和外皮蛋白的比较研究中，透明质蛋白的表达与它们在传染性软疣、角化棘皮瘤和毛母质瘤中共定位。从这项研究中，透明质酸被揭示有密切的功能关系，与其他终末分化的标志物作为前体的皮质细胞包膜的皮肤。
To investigate the function of trichohyalin during terminal differentiation of the skin, immunohistochemical studies were performed on trichohyalin and its related proteins, filaggrin and involucrin, the components of the cornified cell envelope. In skin disorders unrelated to tumours, weak trichohyalin expression was found in a few granular cells or in the horny layer of psoriasis, ichthyosis, keratosis pilaris, porokeratosis, chronic dermatitis and callus. Similar trichohyalin expression was found in epidermal tumours, such as seborrheic keratosis, actinic keratosis, Bowen's disease and well-differentiated squamous cell carcinoma. In follicular tumours, trichohyalin expression was positive in trichoepithelioma, keratotic basal cell epithelioma, proliferating trichilemmal tumour, trichilemmoma, pilomatricoma and keratoacanthoma. From comparative studies with filaggrin and involucrin, trichohyalin expression was co-localized with them in molluscum contagiosum, keratoacanthoma and pilomatricoma. From this study, trichohyalin is revealed to have close functional relationship with other markers of terminal differentiation as a precursor of the cornified cell envelope of the skin.
影响因子：
6.5
作者：
MURPHY, GF;FLYNN, TC;PINKUS, GS
通讯作者：
PINKUS, GS
影响因子：
6.5
作者：
OGUIN, WM;SUN, TT;MANABE, M
通讯作者：
MANABE, M
角蛋白：来自人和牛组织的表皮转谷氨酰胺酶的可溶性底物。
DOI：
10.1073/pnas.81.1.238
发表时间：
1984
影响因子：
11.1
作者：
Zettergren,JG;Peterson,LL;Wuepper,KD
通讯作者：
Wuepper,KD