Streptococcus, the Predominant Bacterium to Predict the Severity of Liver Injury in Alcoholic Liver Disease.
Streptococcus, the Predominant Bacterium to Predict the Severity of Liver Injury in Alcoholic Liver Disease.
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DOI：
10.3389/fcimb.2021.649060
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发表时间：
2021
影响因子：
5.7
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Zhong X;Cui P;Jiang J;Ning C;Liang B;Zhou J;Tian L;Zhang Y;Lei T;Zuo T;Ye L;Huang J;Chen H
新的证据表明，肠道微生物群的失衡与酒精性肝病（ALD）的进展有关，并且ALD患者肠道微生物群的组成发生了改变。然而，参与ALD进展的患者的主要细菌尚未确定。本研究旨在探讨ALD早期和终末期的优势菌及其与肝损伤程度的关系。我们招募了21名酒精性脂肪肝（AFL）患者、17名酒精性肝硬化（ALC）患者和27名健康对照者，并对其粪便微生物群的16S rRNA基因进行了测序。采用典型对应分析（CCA）、spearman相关热图和多变量线性关联模型（MaAsLin）评估肠道菌群组成及其与临床肝功能指标的关系。在ALD的不同阶段，肠道微生物群的组成和结构发生了很大的变化，并且随着ALD的进展，即使在早期，紊乱程度也会加重。链球菌的相对丰度仅在ALC患者中高度富集（P <0.001），且与AST水平呈正相关（P = 0.029）。链球菌丰度将ALC患者的肝损伤与对照组区分开来，其受体-操作特征曲线下面积（AUC）为0.877 （P < 0.001）。这些结果表明，在ALD的早期和终末期都存在肠道菌群失调，且失调程度随着ALD的进展而加重。链球菌作为优势菌，可作为评价ALD患者肝损伤严重程度的微生物标志物。
New evidence implies that the imbalance of gut microbiota is associated with the progression of alcoholic liver disease (ALD) and that the composition of gut microbiota is altered in ALD patients. However, the predominant bacterium in patients involved in the progress of ALD has not been identified. The purpose of this study is to investigate the predominant bacterium in the early and end-stages of ALD as well as the relationship between the bacterium and the degree of liver injury. We enrolled 21 alcoholic fatty liver (AFL) patients, 17 alcoholic liver cirrhosis (ALC) patients and 27 healthy controls, and sequenced the 16S rRNA gene of their fecal microbiota. The gut microbiota composition and its relationship with the indicators of clinical hepatic function were assessed using canonical correspondence analysis (CCA), spearman correlation heatmap and multivariate association with linear (MaAsLin) Models. The composition and structure of gut microbiota changed greatly in different stages of ALD, and the degree of disorder was aggravated with the progression of ALD, even in the early stage. Moreover, the relative abundance of Streptococcus was highly enriched only in patients with ALC (P <0.001), and positively correlated with AST level (P = 0.029). The abundance of Streptococcus distinguished the liver injury of ALC patients from the controls with an area under the receiver-operating characteristic curve (AUC) of 0.877 (P < 0.001). These findings indicate that the imbalance of gut microbiota exists at the early and end-stages of ALD, and the degree of disorder is aggravated with the progression of ALD. Streptococcus, as the predominant bacterium, may be a microbiological marker to evaluate the severity of liver injury in ALD patients.
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