Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction.
Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction.
复制标题
海马，杏仁核和压力：影响成瘾易感性的相互作用系统。
DOI：
10.1111/j.1749-6632.2010.05896.x
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发表时间：
2011-01
影响因子：
5.2
通讯作者：
Grace AA
中科院分区：
文献类型：
--
作者：
Belujon P;Grace AA
Stressis one of the major factors in drug abuse, particularly in relapse and drug-seeking behavior. However, the mechanisms underlying the interactions between stress and drug abuse are unclear. For many years, studies have focused on the role of the dopaminergic reward system in drug abuse. Our results show that an increased dopaminergic activity is induced by drug sensitization and different stressors via potentiation of the ventral subiculum-nucleus accumbens (NAc) pathway. Although the role of the NE system in stress is well-known, its involvement in drug abuse has received less attention. This review explores the different mechanisms by which stressors can modulate the ventral subiculum-accumbens pathway, and how these modulations can induce alterations in the behavioral response to drug administration. In particular, we will focus on two main afferents to the NAc, the basolateral amygdala and the ventral subiculum of the hippocampus, and their interactions with the locus coeruleus-norepinephrine system.
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影响因子：
2.9
作者：
French, SJ;Hailstone, JC;Totterdell, S
通讯作者：
Totterdell, S
影响因子：
3.3
作者：
GRACE, AA;BUNNEY, BS
通讯作者：
BUNNEY, BS
影响因子：
10.6
作者：
Aston-Jones, G;Rajkowski, J;Cohen, J
通讯作者：
Cohen, J
影响因子：
5.2
作者：
Chen BT;Hopf FW;Bonci A
通讯作者：
Bonci A
影响因子：
16.2
作者：
Goto, Y;Grace, AA
通讯作者：
Grace, AA