Bone matrix imaged in vivo by water- and fat-suppressed proton projection MRI (WASPI) of animal and human subjects.
Bone matrix imaged in vivo by water- and fat-suppressed proton projection MRI (WASPI) of animal and human subjects.
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DOI：
10.1002/jmri.22130
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发表时间：
2010-04
影响因子：
4.4
通讯作者：
Glimcher, Melvin J.
中科院分区：
文献类型：
--
作者：
Wu, Yaotang;Hrovat, Mirko I.;Ackerman, Jerome L.;Reese, Timothy G.;Cao, Haihui;Ecklund, Kirsten;Glimcher, Melvin J.
在临床扫描仪中演示水和脂肪抑制质子投影MRI（WASPI），以显示动物和人类受试者的固体骨基质。猪骨标本和聚合物颗粒被用来优化WASPI方法的软组织抑制，图像分辨率，信噪比（SNR），和扫描时间的3 T MRI扫描仪。用优化后的方法对2-3月龄健康约克郡猪的踝关节进行了扫描。该方法也被应用到六个健康的成年人志愿者的手腕，以证明在人类受试者的WASPI方法的可行性。使用无质子材料构建的发射/接收线圈用于产生强B1场。开发了一种快速发送/接收开关，以减少长接收器死区时间，否则会模糊信号。猪脚踝和人手腕的清晰3D WASPI图像，仅显示固体骨基质和其他高固体含量的组织（例如，肌腱），在所有三个维度的空间分辨率为1.6 mm，在短短的18分钟内获得。WASPI的固体基质的骨在人类和动物体内是可行的。
To demonstrate water and fat suppressed proton projection MRI (WASPI) in a clinical scanner to visualize the solid bone matrix in animal and human subjects. Pig bone specimens and polymer pellets were used to optimize the WASPI method in terms of soft tissue suppression, image resolution, signal to noise ratio (SNR), and scan time on a 3T MRI scanner. The ankles of healthy 2–3 month old live Yorkshire pigs were scanned with the optimized method. The method was also applied to the wrists of six healthy adult human volunteers to demonstrate the feasibility of the WASPI method in human subjects. A transmit/receive coil built with proton-free materials was utilized to produce a strong B1 field. A fast transmit/receive switch was developed to reduce the long receiver dead time that would otherwise obscure the signals. Clear 3D WASPI images of pig ankles and human wrists, showing only the solid bone matrix and other tissues with high solid content (e.g., tendons), with a spatial resolution of 1.6 mm in all three dimensions were obtained in as briefly as 18 min. WASPI of the solid matrix of bone in humans and animals in vivo is feasible.
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影响因子：
3.3
作者：
GOLD, GE;PAULY, JM;HERFKENS, RJ
通讯作者：
HERFKENS, RJ
影响因子：
2.2
作者：
Garwood, M;DelaBarre, L
通讯作者：
DelaBarre, L
影响因子：
5.8
作者：
Boutroy, S;Bouxsein, ML;Delmas, PD
通讯作者：
Delmas, PD
DOI：
10.1159/000223692
发表时间：
2009-01-01
期刊：
CALCIUM AND BONE DISORDERS IN CHILDREN AND ADOLESCENTS
影响因子：
--
作者：
Allgrove, Jeremy
通讯作者：
Allgrove, Jeremy
影响因子：
6.2
作者：
Gourion-Arsiquaud, Samuel;Burket, Jayme C.;Boskey, Adele L.
通讯作者：
Boskey, Adele L.